PMID: 41900Nov 1, 1979

The assay and stability of chlorpropamide in solid dispersion with urea

The Journal of Pharmacy and Pharmacology
J L FordM H Rubinstein

Abstract

Thin layer chromatography followed by reflectance densitometry has been used to evaluate the stability of chlorpropamide-urea during the fusion process. Urea was found to decompose to biuret and chlorpropamide to p-chlorobenzenesulphonamide: several other unidentified decomposition products were detected. The energy for decomposition of chlorpropamide was 57.1 kJmol-1 for melts containing 15 and 30% chlorpropamide. Decomposition followed apparent first order kinetics.

References

May 21, 2013·Pharmaceutical Development and Technology·Yusuke ShibataYoshiteru Watanabe

Citations

Mar 1, 1976·The Journal of Pharmacy and Pharmacology·J H Collett, B L Flood
Apr 1, 1976·The Journal of Pharmacy and Pharmacology·J H CollettF R Sale
Nov 1, 1977·The Journal of Pharmacy and Pharmacology·J L Ford, M H Rubinstein
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·G Edwards, R T Calvert
Nov 1, 1978·Journal of Pharmaceutical Sciences·H M El-BannaS A El-Fattah
Nov 1, 1976·Journal of Pharmaceutical Sciences·M P Summers, R P Enever
Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Niazi
Feb 1, 1969·Journal of Pharmaceutical Sciences·K K Kaistha
Mar 30, 1959·Annals of the New York Academy of Sciences·T J TOOLAN, R L WAGNER

Related Concepts

Carmol
Biuret
Chromatography, Qualitative; Thin Layer, Analyte Not Elsewhere Specified
Urea Measurement
Drug Stability
Urea
Assay
Densitometry
Pharmaceutical Excipient
Chlorpropamide

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