The assembly of apoB-containing lipoproteins: a structural biology point of view

Annals of Medicine
Leonard J Banaszak, Wasantha K Ranatunga

Abstract

Atherosclerosis is a widespread disease caused by the deposition of lipids on arterial walls. Such lipid plaques in coronary arteries can be fatal. Although many factors related to diet, life-style, etc. contribute to the worsening of the ailment, the primary cause, the lipids in the circulatory system, come from a series of low-density lipoproteins. These lipoproteins are necessary for the transport of lipids to and from different organs. It would be valuable to medicine and the field of drug design if a more detailed understanding of the organization of lipid and protein in these molecules were available. Unfortunately because of heterogeneity in their size and lipid composition, all classes of the low-density serum lipoproteins appear to be not amenable to the most widely used method for obtaining detailed atomic data - X-ray crystallography. However there appears to be a recently identified homolog that is relatively homogeneous, and crystal structures have been obtained. Used as a molecular model, the homolog serves as a source of conformational information that might help to unravel the processes involved in the lipid loading of the low-density lipoproteins. The review attempts to give a brief summary of the structural bi...Continue Reading

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Citations

Apr 30, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yongyan SongQiaozhu Su
Aug 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ekaterina I BiterovaLloyd W Ruddock
Apr 4, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Julie TsaiKhosrow Adeli

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