The assessment and treatment of water imbalance in patients with psychosis

Clinical Schizophrenia & Related Psychoses
Morris B Goldman

Abstract

Polydipsia and episodic life-threatening water intoxication remain important clinical problems for a significant portion of persons with schizophrenia. The disorders are associated with increased morbidity and mortality from a number of causes. With a basic understanding of the pathophysiology, one can easily diagnose and assess the clinical conditions. We review here the scope and pathophysiology of disordered water imbalance, including both primary and secondary polydipsia and hyponatremia. Reversible factors and possible interventions are reviewed. Treatment options for preventing water intoxication have expanded from discontinuation of offending agents, targeted fluid restriction, and clozapine therapy to the addition of oral vasopressin antagonists. The latter, however, are extremely potent and must be carefully monitored.

References

Feb 18, 1988·The New England Journal of Medicine·M B GoldmanG L Robertson
Mar 1, 1985·The Journal of Nervous and Mental Disease·W V ViewegW W Spradlin
Jun 1, 1993·Biological Psychiatry·D B SchnurS Mukherjee
May 1, 1993·The American Journal of Psychiatry·R C MillsonW B Glackman
Jul 31, 1996·Psychiatry Research·C M Canuso, M B Goldman
Feb 17, 1999·The Journal of Neuropsychiatry and Clinical Neurosciences·C M Canuso, M B Goldman
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·R T Timmer, J M Sands
Aug 24, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·E Mercier-Guidez, G Loas
Aug 31, 2001·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·A G AhmedK V Ramachandran
Apr 23, 2002·British Journal of Clinical Pharmacology·Kris L L MovigAntoine C G Egberts
Nov 30, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·G Loas, E Mercier-Guidez
Apr 2, 2003·The British Journal of Psychiatry : the Journal of Mental Science·K L L MovigA C G Egberts
Jul 9, 2003·Kidney International·Claire PresneJean-Pierre Grünfeld
Jul 24, 2003·American Journal of Physiology. Renal Physiology·Melissa A CadnapaphornchaiRobert W Schrier
Aug 16, 2003·The American Journal of the Medical Sciences·Milos N BudisavljevicDavid W Ploth
Oct 21, 2003·The Annals of Pharmacotherapy·Biff F PalmerMalcolm Lader
Jul 6, 2004·Physiology & Behavior·M J McKinleyB J Oldfield
Jul 29, 2004·Schizophrenia Bulletin·Morris B Goldman, Colin P Mitchell
Aug 5, 2004·The Journal of Clinical Psychiatry·Elie LepkifkerMoshe Kotler
Feb 24, 2005·Journal of Cardiovascular Pharmacology·Margarida AlvelosPatrício Soares-da-Silva
Mar 1, 2006·Schizophrenia Research·Meera JessaniRichard C Josiassen
Apr 8, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Branimir MargetićTija Zarković-Palijan
May 15, 2008·QJM : Monthly Journal of the Association of Physicians·F Gankam KengneG Decaux
Sep 23, 2008·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Michael L Moritz, Juan Carlos Ayus

❮ Previous
Next ❯

Citations

Jul 19, 2013·Neurology India·Subodh Banzal, Abhishek Singhai
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Pascal SakerDerek A Denton
Feb 24, 2011·Journal of Neuropathology and Experimental Neurology·Seymour LevineStephen D Ginsberg
Sep 16, 2014·Perspectives in Psychiatric Care·Peter C KowalskiNorman L Keltner
Jun 6, 2015·Journal of Medical Case Reports·Eri KawataNobuhiko Uoshima
Mar 29, 2012·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Licia Maiocchi, Elsa Bernardi
Jan 17, 2015·Journal of Intensive Care Medicine·Mary Ansley Buffington, Kenneth Abreo
Mar 29, 2012·Clinical Schizophrenia & Related Psychoses·Richard C JosiassenFrank Czerwiec
Mar 8, 2019·The Mental Health Clinician·Deanna L Kelly, Raymond C Love
Aug 15, 2021·Neuropsychopharmacology Reports·UNKNOWN Japanese Society of Neuropsychopharmacology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here