PMID: 22454894Apr 1, 1974Paper

The assessment of β-adrenoceptor blocking drugs in hyperthyroidism

British Journal of Clinical Pharmacology
S G CarruthersR G Shanks


1 Intravenous propranolol and practolol both reduced resting supine heart rate in patients with hyperthyroidism. Propranolol produced a significantly greater reduction than practolol, which did not have a dose-dependent effect. 2 The effect of these drugs on resting heart rate was much less than their effect on the tachycardias produced both by severe exercise and by standing upright in hyperthyroid patients. Propranolol again produced a significantly greater reduction than practolol in each situation, but practolol did have a dose dependent effect on exercise heart rate. 3 The percentage reduction of standing tachycardia produced by the two drugs appeared to parallel closely the reduction in exercise tachycardia. 4 It is concluded that a simple and convenient way of assessing the activity of β-adrenoceptor blocking drugs in hyperthyroid patients would be to measure their effect on the tachycardia induced by standing. Their effect on resting heart rate should not be used. 5 Practolol may be useful in the management of hyperthyroidism in patients in whom propranolol and similar non-selective β-adrenoceptor blocking drugs are contraindicated.


Apr 21, 1973·British Medical Journal·S G CarruthersM J Walsh
Jan 1, 1973·Postgraduate Medical Journal·E M PhillipsD G Ferriman
Jun 23, 1973·British Medical Journal
May 11, 1968·Lancet·D G McDevittJ A Weaver
May 17, 1969·Lancet·R G ShanksD A Montgomery
Dec 1, 1965·British Journal of Pharmacology and Chemotherapy·J W BlackR G Shanks
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Oct 1, 1969·European Journal of Pharmacology·C Raper, J Wale
May 1, 1970·British Journal of Pharmacology·J M Kofi EkueR G Shanks
Sep 26, 1970·British Medical Journal·D J Coltart, D G Shand
Sep 1, 1972·Clinical Pharmacology and Therapeutics·D W SchneckW R Wilson
Jun 1, 1971·Postgraduate Medical Journal·A G Arbab, P Turner
Jul 1, 1968·The Journal of Clinical Pharmacology and the Journal of New Drugs·P Turner, R C Hill
Oct 1, 1969·European Journal of Pharmacology·N SvedmyrR Malmberg
Feb 1, 1974·British Journal of Clinical Pharmacology·J M EkueM J Walsh
Feb 1, 1974·British Journal of Clinical Pharmacology·J M Ekue, R G Shanks

❮ Previous
Next ❯


Jan 1, 1981·European Journal of Clinical Pharmacology·M E EllisS H Ellis
Jan 1, 1988·Pharmacology & Therapeutics·J W UpwardC F George
Aug 28, 1980·The New England Journal of Medicine·C H Emerson, M M El-Zaheri
Oct 1, 1975·British Journal of Clinical Pharmacology·J K Nelson, D G McDevitt
Aug 1, 1977·British Journal of Clinical Pharmacology·D G McDevitt
Sep 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt, J K Nelson
May 1, 1988·Clinical Cardiology·M W WestonG H Lyman
Sep 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·S CalzettiA Richens
Feb 1, 1978·British Heart Journal·P B DecalmerG M Sterling
May 7, 1983·British Medical Journal·T J Wilkin
Jun 1, 1982·British Journal of Clinical Pharmacology·N R PedenJ Crooks
Jan 1, 1984·British Journal of Clinical Pharmacology·M E EllisT J Fitzsimons
Apr 1, 1982·Scottish Medical Journal·E F Nicol, W J Irvine
Nov 1, 1977·Irish Journal of Medical Science·D G McDevitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.