PMID: 22454894Apr 1, 1974Paper

The assessment of β-adrenoceptor blocking drugs in hyperthyroidism

British Journal of Clinical Pharmacology
S G CarruthersR G Shanks

Abstract

1 Intravenous propranolol and practolol both reduced resting supine heart rate in patients with hyperthyroidism. Propranolol produced a significantly greater reduction than practolol, which did not have a dose-dependent effect. 2 The effect of these drugs on resting heart rate was much less than their effect on the tachycardias produced both by severe exercise and by standing upright in hyperthyroid patients. Propranolol again produced a significantly greater reduction than practolol in each situation, but practolol did have a dose dependent effect on exercise heart rate. 3 The percentage reduction of standing tachycardia produced by the two drugs appeared to parallel closely the reduction in exercise tachycardia. 4 It is concluded that a simple and convenient way of assessing the activity of β-adrenoceptor blocking drugs in hyperthyroid patients would be to measure their effect on the tachycardia induced by standing. Their effect on resting heart rate should not be used. 5 Practolol may be useful in the management of hyperthyroidism in patients in whom propranolol and similar non-selective β-adrenoceptor blocking drugs are contraindicated.

References

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Feb 1, 1974·British Journal of Clinical Pharmacology·J M Ekue, R G Shanks

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Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·M E EllisS H Ellis
Jan 1, 1988·Pharmacology & Therapeutics·J W UpwardC F George
Aug 28, 1980·The New England Journal of Medicine·C H Emerson, M M El-Zaheri
Oct 1, 1975·British Journal of Clinical Pharmacology·J K Nelson, D G McDevitt
Aug 1, 1977·British Journal of Clinical Pharmacology·D G McDevitt
Sep 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt, J K Nelson
May 1, 1988·Clinical Cardiology·M W WestonG H Lyman
Sep 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·S CalzettiA Richens
Feb 1, 1978·British Heart Journal·P B DecalmerG M Sterling
May 7, 1983·British Medical Journal·T J Wilkin
Jun 1, 1982·British Journal of Clinical Pharmacology·N R PedenJ Crooks
Jan 1, 1984·British Journal of Clinical Pharmacology·M E EllisT J Fitzsimons
Apr 1, 1982·Scottish Medical Journal·E F Nicol, W J Irvine
Nov 1, 1977·Irish Journal of Medical Science·D G McDevitt

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