PMID: 2501381Jan 1, 1989Paper

The assessment of a cycle with clomiphene as an indicator for further treatment

Journal of Endocrinological Investigation
Z ShohamB Lunenfeld

Abstract

A group of 15 anovulatory women was treated during one single cycle with clomiphene citrate (CC) 100 mg daily, starting on day 5 of the cycle for 5 days, (group A). Eleven ovulatory patients represent a control group (group B). Serum levels of follicular stimulating hormone (FSH) and luteinizing hormone (LH) were determined on day 5 and 9 of the cycle. Follicular growth was assessed by ultrasound from day 9 until presumed ovulation. Estradiol levels and cervical mucus characteristics were measured on day 14 and progesterone assessed on day 23 of the cycle. In the clomiphene induced cycles FSH and LH values on day 9 were significantly above pretreatment levels (p less than 0.001 and p less than 0.0001, respectively), and above those of day 9 of the control group (p less than 0.0001). In comparison to the control group under CC treatment, an excessive production of estradiol was observed (p less than 0.0001) corresponding to significant increase in number of follicles (over 15 mm in diameter), p less than 0.04. Inspite this elevated estradiol, the cervical score was significantly lower (p less than 0.004) than in the control group. Three patients out of the 15 were characterized by a discrepancy between elevated estradiol levels ...Continue Reading

References

Jul 1, 1977·Fertility and Sterility·J GarciaA C Wentz
Aug 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J F KerinS S Yen
Nov 15, 1974·American Journal of Obstetrics and Gynecology·L A RustD R Mishell
Mar 1, 1971·Fertility and Sterility·G Graff
Oct 14, 1961·JAMA : the Journal of the American Medical Association·R B GREENBLATTA W RAY

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Citations

Jun 1, 1993·Baillière's Clinical Obstetrics and Gynaecology·T C Li, M A Warren
Aug 7, 2004·Journal of Periodontology·M Cenk HaytaçGulash Seydaoglu

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