The assessment of correlation and prognosis among 18 F-FDG uptake parameters, Glut1, pStat1 and pStat3 in surgically resected non-small cell lung cancer patients

Oncotarget
Hayato KaidaMasatoshi Ishibashi

Abstract

To assess the correlation among 18F-FDG uptake, Glut1, pStat1 and pStat3, and to investigate the relationship between the prognosis and 18F-FDG uptake and these molecular markers in surgically resected non-small cell lung cancer (NSCLC) patients. Knockdown of Glut1 led to a significant increase in pStat1 expression. Glut1 expression positively correlated with the SUVmax, SUVmean, and TLG significantly (P<0.001). pStat3 expression negatively correlated with all PET parameters significantly (P<0.001). pStat1 had positive weak correlations with the SUVmax and SUVmean. All PET parameters and Glut1 were significantly associated with DFS (P<0.05). TLG, MTV, Glut1 and pStat1 were significantly associated with OS (P<0.05). pStat3 and Glut1 may be associated with 18F-FDG uptake mechanism. TLG, MTV, and Glut1 may be independent prognostic factors. The SUVmax, SUVmean, MTV and TLG of primary lesions were calculated in 140 patients. The expressions of Glut1 and Stat pathway proteins in NSCLC cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry. OS and DFS were evaluated by the Kaplan-Meier method. The difference in survival between subgroups was analyzed by log-rank test. The prognostic signif...Continue Reading

References

Oct 1, 2003·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·Steven M. LarsonRobert Ginsberg
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric B HauraGerold Bepler
Dec 4, 2008·British Journal of Cancer·M I Galleges RuizG Giaccone
Jun 9, 2009·PloS One·Nikolai N KhodarevRalph R Weichselbaum
Jul 9, 2009·Chest·Frank C DetterbeckLynn T Tanoue
Nov 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Christophe Van de WieleAlex Maes
Aug 7, 2013·Journal of Nuclear Medicine Technology·Eric LaffonRoger Marthan
Dec 18, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y H Xu, S Lu
Dec 25, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kyoichi KairaNobuyuki Yamamoto
Jan 24, 2014·AJR. American Journal of Roentgenology·Vasavi PaidpallyRathan M Subramaniam
Aug 30, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Olga C J SchuurbiersJohan Bussink
Oct 1, 2014·Cancer Research·Budiman KharmaIkuo Konishi
Oct 25, 2014·Nature Reviews. Cancer·Hua YuRichard Jove
Dec 20, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Seong Yong ParkKyung Young Chung
Jan 23, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A L WongB C Goh
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 27, 2016·European Journal of Radiology·Hayato KaidaMasatoshi Ishibashi
Feb 19, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Young Wha KohSeong Yong Park

❮ Previous
Next ❯

Citations

May 20, 2020·Therapeutic Advances in Medical Oncology·Jinguo ZhangGuoxiong Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
Assay
surgical resection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.