PMID: 3097221Jan 1, 1986Paper

The assessment of gas exchange by automated analysis of O2 and CO2 alveolar to arterial differences

International Journal of Clinical Monitoring and Computing
P PaolettiC Giuntini


A computer program to measure breath by breath alveolar pressure (PA) and alveolar to arterial difference (AaD) for O2 and CO2, by a mass-spectrometer has been implemented. The program allows the determination of alveolar gas by different methods: 1. Bohr's equation (BE); 2. ideal alveolar air equation for O2 (IDO2); 3. end-tidal (ET); 4. by the Rahn's definition of 'mean alveolar gas', i.e., alveolar pressures are defined when instantaneous respiratory exchange ratio (IRQ) equals mean respiratory exchange ratio (MRQ). This automated technique has been used in 16 patients with chronic obstructive lung disease (COLD) and 15 patients with pulmonary embolism (APE). In both groups of patients it was always possible to find in each breath the point where IRQ = MRQ and therefore to measure AaD by RD. IDO2 was significantly lower than PAO2 by the other methods. Also ET values of O2 and CO2 were significantly different from RD and BE in both groups of patients, however the difference was consistently higher in COLD patients. The different shape of the expirograms (steeper expirograms in COLD) is responsible for this different result. RD and BE AaD characterize gas exchange more precisely than ET, because the contribution of high VA/Q u...Continue Reading


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Jan 1, 1978·Circulation Research·D R DantzkerJ B West
Feb 1, 1977·The Journal of Clinical Investigation·P D WagnerJ B West
Jul 1, 1975·Journal of Applied Physiology·S E Levy, D H Simmons
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·A SantolicandroC Giuntini
May 1, 1957·Journal of Applied Physiology·J W SEVERINGHAUS, M STUPFEL
Feb 11, 1960·The New England Journal of Medicine·E D ROBIND M TRAVIS
May 1, 1960·Journal of Applied Physiology·B B ROSS, L E FARHI
May 1, 1963·Journal of Applied Physiology·M C HartC D Cook


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