PMID: 9547894Apr 21, 1998Paper

The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients

Annals of Clinical Biochemistry
J M WallaceJ J Strain

Abstract

Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28), angina patients (n = 25), and control subjects (n = 27). Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher in the post MI group compared to both the control and angina groups (P < or = 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF. High concentrations of PDGF in the circulation could further accelerate the progression of the disease.

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Citations

Feb 22, 2012·International Journal of Cardiology·Sally J Aldous
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G CiancioloV Stefoni
Sep 17, 2014·BMC Infectious Diseases·Kariuki H NjaanakeBenson B Estambale
Jan 10, 2003·The International Journal of Artificial Organs·G DonatiS Stefoni

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