PMID: 9192550Jan 1, 1997Paper

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in human benign and malignant epithelial lesions of the parotid gland

Oral Oncology
Q ZhuG L Tipoe

Abstract

Immunoreactivity of proliferating cell nuclear antigen (PCNA) was assessed in formalin-fixed, paraffin-embedded sections from human normal parotid gland (N; n = 12), chronic sialadenitis (CS; n = 8), Warthin's tumour (W; n = 10), benign pleomorphic adenoma (BPA; n = 11), mucoepidermoid carcinoma (MEC; n = 14), carcinoma in pleomorphic adenoma (CPA; n = 10) and adenoid cystic carcinoma (ACC; n = 12) of the parotid gland, using the monoclonal antibody PC 10. The morphometric parameters measured comprised PCNA labelling induces (PI = the numerical percentage of PCNA positive nuclei) and volume densities of PCNA positive nuclei(VV, PEP = the relative volume of positive nuclei per unit volume of reference epithelium). All parameters were expressed in relation to total positive, as well as to strongly- and weakly-positive nuclei. In general, the values of PCNA parameters increased progressively in benign lesions in comparison with the N group, and in malignant neoplasms in comparison with non-neoplastic groups and benign lesions. The strongly-positive parameters showed more statistically significant differences than weakly-positive ones, suggesting that weakly-stained nuclei may include some non-cycling cells and, therefore, that wea...Continue Reading

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Citations

Oct 12, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·C Y LiT Kiyoshima
Nov 13, 2002·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Ulrike EbensbergerAndreas Filippi
Jan 9, 2004·Oncogene·Marianne L VozWim J M Van de Ven
Aug 4, 2004·Journal of Oral Science·Elena Riet Correa RiveroMaria Cassia Ferreira de Aguiar

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