PMID: 19915293Nov 17, 2009Paper

The assessment of pulmonary diffusing capacity in diabetes mellitus with regard to microalbuminuria

Internal Medicine
Tayyibe SalerMustafa Yenigun

Abstract

The current study was conducted to determine whether or not the lung is one of the target organs in the development of vascular complications in diabetic patients. We also investigated the relationship between pulmonary diffusing capacity and microalbuminuria. A total of 68 patients with type 2 diabetes and 44 with type 1 diabetes (male/female [M/F] n=19/49 and 15/29; age: 52.4+/-8.8 and 32.5+/-11 years;) and 80 healthy controls (M/F=22/58; age=40.1+/-12.4 years) were recruited for the study. All of the participants were evaluated with simple spirometric tests and a simple breath carbon monoxide (CO) diffusion test. CO lung diffusion capacity (DLCO) and the ratio of DLCO value to the alveolar volume (VA) were used to assess alveolar membrane permeability (DLCO/VA). Urinary albumin excretion (UAE) per day of the participants was also evaluated. DLCO, DLCO% and DLCO/VA% values were significantly lower in diabetics than in the control group (p=0.006; p=0.039; p=0.003, respectively). UAE was inversely correlated with DLCO, DLCO/VA, DLCO/VA% and DLCO% (p=0.050; p=<0.001; p=0.001; p=0.004, respectively). This study demonstrated that alveolar gas exchange capacity is significantly decreased in diabetic patients. Microalbuminuria may b...Continue Reading

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Citations

Oct 30, 2012·Cardiovascular Diabetology·Aibek E Mirrakhimov
Jul 22, 2015·Revue de pneumologie clinique·C Fontaine-DelaruelleS Couraud
Jan 9, 2016·European Journal of Medical Research·Robert RozenbergStephan F E Praet
Nov 26, 2015·Journal of Diabetes and Its Complications·Peter ĎurdíkMiriam Čiljaková
May 23, 2013·Clinical Physiology and Functional Imaging·Birgitta SchmekelPer Venge
Jul 6, 2016·Biochemical and Biophysical Research Communications·Xiaoyan LiuTanzhen Liu
Jul 30, 2020·The Journal of International Medical Research·Melvin R Hayden
Jun 2, 2020·Journal of Anesthesia·Zhaosheng JinDaqing Ma
Sep 14, 2010·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Fabio Cangeri Di NasoNorma Anair Possa Marroni
Feb 12, 2021·ERJ Open Research·Jesús Díez-Manglano, Uxua Asìn Samper

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