The assessment of time-of-flight on image quality and quantification with reduced administered activity and scan times in 18F-FDG PET

Nuclear Medicine Communications
Ian S ArmstrongJ C Matthews

Abstract

The last decade has seen considerable technological innovations in PET detectors with the availability, among other advances, of time-of-flight (TOF). TOF has been shown to increase the signal-to-noise ratio (SNR), which should allow for a reduction in acquired counts while maintaining image quality. Fifty-eight patients referred for routine F-flurodeoxyglucose ((18)F-FDG) oncology PET studies were included in this study. Patients with weight below or above 100 kg were prescribed 350 or 400 MBq of (18)F-FDG, respectively. Listmode data were acquired for 2.5 min per bed position and reconstructed with ordered-subset expectation maximization (OSEM) reconstruction. TOF reconstruction was performed on reduced-count data, with two levels of reduction (-20 and -40% for patients <100 kg and -16 and -30% for patients >100 kg) achieved by clipping the listmode data. Liver SNR, mediastinum mean standardized uptake value (SUV(mean)), and lesion maximum standardized uptake value (SUV(max)) were measured in all images. All images were visually assessed as adequate or suboptimal. No significant difference was seen in mediastinum SUV(mean) or lesion SUV(max) when comparing reduced-count TOF with full-count OSEM images. Compared with the origi...Continue Reading

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Citations

Nov 26, 2015·Nihon Hoshasen Gijutsu Gakkai zasshi·Go Akamatsu
Dec 2, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Spencer C BehrYoungho Seo
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May 13, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
Oct 1, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Arman RahmimRichard L Wahl

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Software Mentioned

Siemens TrueD image
OSEM
ARSAC
StatsDirect

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