The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth

American Journal of Obstetrics and Gynecology
Martha L BustosEunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

Abstract

Infants born <37 weeks' gestation are of public health concern since complications associated with preterm birth are the leading cause of mortality in children <5 years of age and a major cause of morbidity and lifelong disability. The administration of 17-alpha hydroxyprogesterone caproate reduces preterm birth by 33% in women with history of spontaneous preterm birth. We demonstrated previously that plasma concentrations of 17-alpha hydroxyprogesterone caproate vary widely among pregnant women and that women with 17-alpha hydroxyprogesterone caproate plasma concentrations in the lowest quartile had spontaneous preterm birth rates of 40% vs rates of 25% in those women with higher concentrations. Thus, plasma concentrations are an important factor in determining drug efficacy but the reason 17-alpha hydroxyprogesterone caproate plasma concentrations vary so much is unclear. Predominantly, 17-alpha hydroxyprogesterone caproate is metabolized by CYP3A4 and CYP3A5 enzymes. We sought to: (1) determine the relation between 17-alpha hydroxyprogesterone caproate plasma concentrations and single nucleotide polymorphisms in CYP3A4 and CYP3A5; (2) test the association between progesterone receptor single nucleotide polymorphisms and spon...Continue Reading

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Citations

Nov 28, 2018·The Cochrane Database of Systematic Reviews·Philippa MiddletonMaria Makrides
Oct 3, 2017·Biological & Pharmaceutical Bulletin·Yuki AsaiMiki Katoh
Dec 15, 2017·CPT: Pharmacometrics & Systems Pharmacology·Sara K QuinneyDavid M Haas
Dec 19, 2017·American Journal of Obstetrics and Gynecology·Jerome F StraussHarvey A Schenkein
May 14, 2021·Frontiers in Genetics·Julia do Amaral GomesHedvig Marie Egeland Nordeng

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