Jun 1, 1976

The association between acidification and electrogenic events in the rat proximal jejunum

The Journal of Physiology
M L Lucas


1. Simultaneous measurement of hydrogen ion production, transmural potential difference and intermittent short-circuit current (SCC) was made in the rat proximal jejunum in vitro: similarly, potassium and sodium ion movements were measured to investigate the relationship of acidification to electrogenic events and associated ion movements in the jejunum.2. Acidification correlated significantly with the short-circuit current and both were inhibited by 10 mM serosal ouabain or 10 mM mucosal aminophylline. Both inhibitors had effects on net potassium movement but not on net sodium movement. Moreover, in isotope studies whereas 10 mM serosal ouabain reduced the J(ms) sodium flux, 10 mM mucosal aminophylline had no effect, i.e. aminophylline can reduce both short-circuit current and acidification without perceptibly altering the serosally directed sodium flux.3. In low-sodium buffers in which acidification still occurs although reduced, transmural potential differences occur of reversed polarity that are apparently unrelated to sodium diffusion potential differences (as evidenced by isotopic sodium efflux experiments) and which could be caused by hydrogen ion production. In low sodium buffers however the inhibitors have opposing ef...Continue Reading

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Mentioned in this Paper

Malignant Neoplasm of Jejunum
Transmural Infarct
Sodium Isotopes

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