The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson's disease

Brain Imaging and Behavior
Martin GorgesJan Kassubek

Abstract

Patients with Parkinson's disease (PD) present with eye movement disturbances that accompany the cardinal motor symptoms. Previous studies have consistently found evidence that large-scale functional networks are critically involved in eye movement control. We challenged the hypothesis that altered eye movement control in patients with PD is closely related to alterations of whole-brain functional connectivity in association with the neurodegenerative process. Saccadic and pursuit eye movements by video-oculography and 'resting-state' functional MRI (3 Tesla) were recorded from 53 subjects, i.e. 31 patients with PD and 22 matched healthy controls. Video-oculographically, a broad spectrum of eye movement impairments was demonstrated in PD patients vs. controls, including interrupted smooth pursuit, hypometric saccades, and a high distractibility in anti-saccades. Significant correlations between altered oculomotor parameters and functional connectivity measures were observed, i.e. the worse the oculomotor performance was, the more the regional functional connectivity in cortical, limbic, thalamic, cerebellar, and brainstem areas was decreased. Remarkably, decreased connectivity between major nodes of the default mode network was...Continue Reading

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Citations

Jan 15, 2016·Journal of Neurology·Hans-Peter MüllerMichael Orth
Jan 9, 2016·Neurochemistry International·Melinda BarkhuizenAnne F Grobler
Jan 26, 2016·Expert Review of Neurotherapeutics·Jan Kassubek, Hans-Peter Müller
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Feb 27, 2018·Journal of Parkinson's Disease·Kristina RosqvistPer Odin
Jun 18, 2019·Therapeutic Advances in Neurological Disorders·Martin GorgesJan Kassubek
May 26, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Johannes RosskopfJan Kassubek
Mar 7, 2019·Movement Disorders Clinical Practice·Massimo FilippiFederica Agosta
Jul 9, 2017·Scientific Reports·Rossana MastrandreaTommaso Gili
Feb 23, 2021·Journal of Parkinson's Disease·Panagiota TsitsiIoanna Markaki
Mar 21, 2021·Neuropsychology Review·Josefine WaldthalerLars Timmermann
Jul 29, 2021·Clinical Parkinsonism & Related Disorders·Karen Frei

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