The association between antihypertensive drug therapies and plasma lipid levels in the general population

Journal of Human Hypertension
A H Maitland-van der ZeeA de Boer

Abstract

To assess the association between different antihypertensive drug regimens and plasma lipid levels in the general population. The Monitoring Project on Cardiovascular Risk Factors was conducted from 1987 to 1991 as a cross-sectional study in The Netherlands. Antihypertensive drug-users and untreated hypertensives were selected. After exclusion of users of cholesterol-lowering drugs 2997 subjects remained for the analysis. The plasma lipid concentrations of the users and non-users of antihypertensives were compared by multiple linear regression. In the univariate analysis patients using beta-blockers had lower high-density lipoprotein (HDL) concentrations (1.13 mmol/l, P < 0.05) and higher cholesterol ratios (5.74, P < 0.05) than untreated hypertensives (Total cholesterol = 6.07 mmol/l, HDL = 1.20 mmol/l and ratio = 5.44). Patients using diuretics had higher total cholesterol levels (6.34 mmol/l) and higher HDL levels (1.26 mmol/l) compared to untreated hypertensives. After adjustment for possible confounders these differences were smaller and no longer statistically significant. After adjustment we found a significant lower HDL cholesterol (mean difference of -0.10 mmol/l, P < 0.05) for users of a combination of a beta-blocker ...Continue Reading

References

Jan 1, 1993·Journal of Cardiovascular Pharmacology·P WeidmannL Böhlen
Feb 11, 1995·Lancet·G K GoodeA M Heagerty
Jan 15, 1995·Annals of Internal Medicine·B L KasiskeT A Louis
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·L G HowesG C Rennie
Sep 30, 1996·The American Journal of Medicine·M R WeirW B Applegate
Jun 17, 1998·JAMA : the Journal of the American Medical Association·M Moser
Sep 24, 1998·Journal of Hypertension·O H KlungelA Bakker

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Citations

Jul 17, 2008·Vascular Health and Risk Management·Panagiotis C Stafylas, Pantelis A Sarafidis
Jun 5, 2012·Vascular Health and Risk Management·Gastone Leonetti, Colin G Egan
Nov 18, 2011·American Journal of Hypertension·Steven M SmithJohn G Gums
Apr 12, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·John A PapadakisEmmanuel S Ganotakis
Aug 11, 2005·Canadian Journal of Physiology and Pharmacology·Márcia M S BernikEder C R Quintão

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