PMID: 11337218May 5, 2001Paper

The association between antiulcer medication and initiation of cobalamin replacement in older persons

Journal of Clinical Epidemiology
S L Mitchell, K Rockwood

Abstract

As chronic use of antiulcer medications might predispose older persons to cobalamin deficiency, we studied participants (> 65 years) in the clinical examination of the Canadian Study of Health and Aging to test the association between the use of an antiulcer medication (histamine-2 blocker or proton pump inhibitor) at baseline with initiation of cobalamin replacement during the 5 year follow-up period. Of 1054 eligible subjects, 125 (11.7%) were taking an antiulcer medication at baseline. At follow-up, 49 (4.6%) had started cobalamin replacement. Antiulcer medication use at baseline was significantly associated with the initiation of cobalamin therapy (odds ratio 2.56, 95% confidence interval 1.30-5.05), even after adjusting for age, gender and institutional residence (odds ratio 2.61, 95% confidence interval 1.31-5.23). There is an independent association between the use of antiulcer medication and initiation of cobalamin therapy. While the relationship is not unambiguously causal, this finding underscores the need for judicious prescribing of antiulcer medications for older persons.

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Citations

Feb 7, 2002·Pharmacoepidemiology and Drug Safety
May 23, 2012·ACS Combinatorial Science·Chul-Hee ChoRichard C Larock
May 28, 2010·Neuropsychiatric Disease and Treatment·Steven F Werder
May 19, 2010·World Journal of Gastroenterology : WJG·Alan B R ThomsonHolly Kamitakahara
Apr 2, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Cristóbal de la Coba OrtizFroilán Giganto Tomé
Jan 26, 2006·Basic & Clinical Pharmacology & Toxicology·Robert T Jensen
Sep 18, 2016·Journal of Diabetes and Its Complications·Christian S HansenJesper Fleischer
Jan 30, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Nathália Dalcin Vomero, Elisângela Colpo
May 4, 2017·Expert Opinion on Drug Metabolism & Toxicology·Emily ReeveSarah N Hilmer
Sep 14, 2006·Pharmacological Reviews·Sharon J Gardiner, Evan J Begg
Sep 2, 2017·Therapeutic Advances in Drug Safety·Marina L MaesSunny Anne Linnebur
Jul 2, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Michael Wakeman, David T Archer
Apr 18, 2013·Annals of Clinical Biochemistry·Catherine F HughesHelene McNulty

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