The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

International Journal of Environmental Research and Public Health
Jin YanGuoxin Zhang

Abstract

Arrhythmia is a common disease around the world and Helicobacter pylori (H. pylori) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori. We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori. In the arrhythmia group, 392 (58.1%) were H. pylori-positive and in the control group 640 (47.8%) were H. pylori-positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081-2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may exist and H. pylori eradication may decrease the occurrence of arrhythmia, especially in Asia and Africa.

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Citations

Apr 26, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Jannis KountourasStergios A Polyzos
May 25, 2020·Journal of Neurology·Mohamed Fahmy DoheimAmeer E Hassan
Feb 10, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Cecilia TettaSandro Gelsomino
Apr 16, 2019·Therapeutic Advances in Gastroenterology·Michelle T LongRobert H Helm
Mar 18, 2020·European Journal of Epidemiology·Lazaros BelbasisEvangelos Evangelou

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