The Association Between Arthralgia and Vedolizumab Using Natural Language Processing.

Inflammatory Bowel Diseases
Tianrun CaiKatherine P Liao

Abstract

The gut-selective nature of vedolizumab has raised questions regarding increased joint pain or arthralgia with its use in inflammatory bowel disease (IBD) patients. As arthralgias are seldom coded and thus difficult to study, few studies have examined the comparative risk of arthralgia between vedolizumab and tumor necrosis factor inhibitor (TNFi). Our objectives were to evaluate the application of natural language processing (NLP) to identify arthralgia in the clinical notes and to compare the risk of arthralgia between vedolizumab and TNFi in IBD. We performed a retrospective study using a validated electronic medical record (EMR)-based IBD cohort from 2 large tertiary care centers. The index date was the first date of vedolizumab or TNFi prescription. Baseline covariates were assessed 1 year before the index date; patients were followed 1 year after the index date. The primary outcome was arthralgia, defined using NLP. Using inverse probability of treatment weight to balance the cohorts, we then constructed Cox regression models to calculate the hazard ratio (HR) for arthralgia in the vedolizumab and TNFi groups. We studied 367 IBD patients on vedolizumab and 1218 IBD patients on TNFi. Patients on vedolizumab were older (mea...Continue Reading

References

Apr 18, 2002·Journal of Clinical Gastroenterology·Sunna GudlaugsdottirJ H Paul Wilson
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Jun 3, 2015·Current Gastroenterology Reports·Mark Löwenberg, Geert D'Haens
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Apr 3, 2016·Alimentary Pharmacology & Therapeutics·D C BaumgartUNKNOWN Vedolizumab Germany Consortium

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Citations

Mar 1, 2020·Gut·Nasim Sadat Seyed TabibSéverine Vermeire
Jan 20, 2019·Nature Reviews. Gastroenterology & Hepatology·Pablo OliveraLaurent Peyrin-Biroulet
Jul 12, 2019·World Journal of Gastroenterology : WJG·Ka-Shing CheungWai-Kay Seto
Feb 29, 2020·Digestive Diseases and Sciences·Fredy Nehme, Keith Feldman
Feb 25, 2021·Journal of Gastroenterology and Hepatology·Chen-Ya Kuo, Han-Mo Chiu
Feb 7, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Aleksander LenertSujin Kim

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