Abstract
To measure the association between asthma drugs and death or ICU admission due to asthma (severe life-threatening attack of asthma [SLTA]), and to assess the possibility that these associations may not be causal but due to the prescription of these drugs to patients with more severe disease (confounding). Retrospective cohort study of 655 asthmatics who attended an emergency department in 1986 to 1987 followed till death or May 1989. Outcome events were death or ICU admission due to asthma (SLTA). All hospital attendances were identified and patients classified at each according to drug exposure and a wide variety of measures of asthma severity. Incidence rates were computed as total outcome events divided by person-time contributed for each subject classified according to drug use and asthma severity. Rate ratio (RR) estimates for severe asthma outcomes associated with use as compared to nonuse of asthma drugs were calculated. Severity markers were identified and used to adjust the crude RR estimates. One hundred five SLTAs (15 deaths, 90 ICU admissions) occurred in 66 patients. Like inhaled fenoterol, oral beta-agonists, theophylline, cromolyn, inhaled steroids, and oral steroids were all associated with an increased risk of ...Continue Reading
References
Feb 20, 1992·The New England Journal of Medicine·W O SpitzerA S Rebuck
Feb 1, 1991·Thorax·J GraingerR Beasley
Mar 1, 1990·Thorax·N PearceR Beasley
Aug 1, 1990·Thorax·W O Spitzer, A S Buist
Apr 29, 1989·Lancet·J CraneR Beasley
Mar 1, 1994·The European Respiratory Journal·C BurgessR Beasley
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·S SuissaW O Spitzer
Nov 1, 1996·Thorax·J E GarrettH H Rea
Citations
May 21, 2011·Clinical Reviews in Allergy & Immunology·Jason Y AdamsTimothy E Albertson
Jun 30, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P J Hannaway
Feb 4, 2003·Journal of Psychoactive Drugs·George S YacoubianRonald J Peters
Jan 21, 2000·Australian and New Zealand Journal of Public Health·B B JalaludinS R Leeder
Nov 20, 1998·BMJ : British Medical Journal·M SextonD Schmeidler
Nov 18, 2000·Thorax·J KolbeJ Garrett
Aug 29, 2006·Thorax·L van der MerweE M van Schalkwyk
May 13, 1998·Thorax·J KolbeG Elkind
Sep 19, 1998·Thorax·J KolbeJ Garrett
Oct 5, 2007·International Archives of Allergy and Immunology·Mostafa MoinMehdi Mazloumi
Oct 23, 1997·Chest·N PearceR Beasley
Nov 14, 2006·Chest·Carolyn S CalfeeMark D Eisner
May 10, 2005·Respiratory Medicine·J SalamzadehH Chrystyn
Jun 21, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Fiona MoghaddasEli Dabscheck