The association between biomarkers and clinical outcomes in novel coronavirus pneumonia in a US cohort

Biomarkers in Medicine
Shant AyanianK. Teufel

Abstract

Aim: To describe the association between D-dimer, CRP, IL-6, ferritin, LDH and the clinical outcomes in a cohort of 299 novel coronavirus disease (COVID-19) patients treated on the inpatient medical service at a university hospital in the District of Columbia (DC, USA). Methodology/results: In this retrospective study, we included all laboratory confirmed COVID-19 adults admitted to the inpatient medicine service at the George Washington University Hospital between March 12, 2020 and May 9, 2020. We analyzed the association of biomarkers on intensive care unit transfer, intubation and mortality. Threshold values for all biomarkers were found to be statistically significant and independently associated with higher odds of clinical deterioration and death. Conclusion: Laboratory markers of inflammation and coagulopathy can help clinicians identify patients who are at high risk for clinical deterioration in COVID-19.

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Citations

Oct 21, 2020·Journal of Clinical Laboratory Analysis·Linlin ChengYongzhe Li
Jan 5, 2021·Cytometry. Part B, Clinical Cytometry·Suraj Saksena, Pratip Chattopadhyay
Jan 12, 2021·Biomarkers in Medicine·Lucy Chard
Feb 5, 2021·Journal of Racial and Ethnic Health Disparities·Rizwan MuhammadAlem Mehari
Mar 21, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Awais AhmedSunil G Sheth
Mar 27, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Giovanni PontiAldo Tomasi
Mar 30, 2021·SN Comprehensive Clinical Medicine·Marcos Edgar Fernández-CuadrosOlga Susana Pérez-Moro
May 12, 2021·Chemico-biological Interactions·Anna-Maria Barciszewska
May 29, 2021·Scientific Reports·Daniel Morell-GarciaAna García-Raja
Jun 12, 2021·Frontiers in Medicine·Yayun LiGuangtong Deng
Aug 27, 2021·Immunity, Inflammation and Disease·Moudhi AlroomiHassan Abdelnaby
Sep 24, 2021·Statistics in Medicine·Peng Jin, Mengling Liu

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