The association between blood pressure components and cognitive functions and cognitive reserve

Clinical and Experimental Hypertension : CHE
Houman Alipour, Mohamad Goldust

Abstract

Hypertension exerts a subtle impact on the brain that is revealed by diminished cognitive function. This study aimed at evaluating the association between blood pressure components and cognitive functions and cognitive reserve. In this cross-sectional study, 500 subjects from general population were evaluated. All neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 s (MI-10) (-32%, p = 0.043), clock drawing test (CLOX) (-26%, p < 0.001), and mini-mental state examination (MMSE) (-7.4%, p = 0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (OR, 0.94, p = 0.032; OR 0.96, p < 0.001; OR 0.94, p < 0.001) and higher pulse pressure (BP) (OR 0.95, p = 0.04; OR 0.97, p < 0.001; and OR 0.92, p < 0.001). The cognitive reserve index (CRI) was 8% lower in the HT (p = 0.04) and was predicted by higher pulse BP (OR 0.86, p < 0.001). The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic. This study contributes ...Continue Reading

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Citations

Sep 27, 2019·Dementia & Neuropsychologia·Natália Cristina MoraesMônica Sanches Yassuda
Mar 23, 2018·Frontiers in Aging Neuroscience·Jeffery M ReddanAndrew Pipingas
Jul 7, 2020·Arquivos de neuro-psiquiatria·Natália Cristina MoraesMonica Sanches Yassuda
Sep 10, 2020·Journal of Diabetes and Its Complications·Serena LowSu Chi Lim

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