The association between breastmilk oligosaccharides and faecal microbiota in healthy breastfed infants at two, six, and twelve weeks of age.

Scientific Reports
Klaudyna BorewiczHauke Smidt

Abstract

Several factors affect gut microbiota development in early life, among which breastfeeding plays a key role. We followed 24 mother-infant pairs to investigate the associations between concentrations of selected human milk oligosaccharides (HMOs) in breastmilk, infant faeces, and the faecal microbiota composition in healthy, breastfed infants at two, six and 12 weeks of age. Lactation duration had a significant effect on breastmilk HMO content, which decreased with time, except for 3-fucosyllactose (3FL) and Lacto-N-fucopentaose III (LNFP III). We confirmed that microbiota composition was strongly influenced by infant age and was associated with mode of delivery and breastmilk LNFP III concentration at two weeks, with infant sex, delivery mode, and concentrations of 3'sialyllactose (3'SL) in milk at six weeks, and infant sex and Lacto-N-hexaose (LNH) in milk at 12 weeks of age. Correlations between levels of individual breastmilk HMOs and relative abundance of OTUs found in infant faeces, including the most predominant Bifidobacterium OTUs, were weak and varied with age. The faecal concentration of HMOs decreased with age and were strongly and negatively correlated with relative abundance of OTUs within genera Bifidobacterium, P...Continue Reading

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Citations

May 28, 2020·Nutrients·Yarden Golan, Yehuda G Assaraf
Aug 14, 2020·Journal of Clinical Medicine·Abraham AjayiStella Smith
Apr 4, 2021·Metabolic Engineering·Angela ZhangShota Atsumi
Jul 3, 2021·Foods·Cristina SánchezMaría Paz Lorenzo
Aug 28, 2021·Nutrients·Buket SoyyılmazLouise Kristine Vigsnæs
Sep 2, 2021·Applied and Environmental Microbiology·Gerald W Tannock

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Methods Mentioned

BETA
PCA
PCR

Software Mentioned

Canoco5
NG
QIIME
R
Tax

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