The association between cagA+ H. pylori infection and distal gastric cancer: a proposed model

Digestive Diseases and Sciences
Mohammed S Al-MarhoonRoger W Soames

Abstract

Cytotoxin-associated gene A (cagA)+ infection is associated with an increased risk of distal gastric cancer. The aim was to determine the effect of Helicobacter pylori (HP) on gastric mucus thickness, hydrophobicity, and PGE2 and their relation to colonization density. Ninety-nine patients were recruited (69 HP- and 30 HP+: 10 cagA+, 18 cagA-, 2 undetermined) and six biopsies were obtained from each patient. Mucus thickness, hydrophobicity, PGE2, and colonization density were determined. HP status was assessed by histology and culture; cagA+ was determined by PCR. In age- and sex-matched patients, PGE2 was greater in PH+ than HP- (P = 0.04), with cagA+ having higher PGE2 than HP- patients (P = 0.031). No differences were observed in mucus thickness (P = 0.717) or hydrophobicity (P = 0.27) between HP+ and HP- patients. However, cagA+ showed a nonsignificant trend of increase in mucus thickness (P = 0.784) and hydrophobicity (P = 0.30) compared to cagA- and HP- patients. cagA+ colonization density was weakly correlated with increased thickness (r = 0.333, P = 0.381), whereas cagA- density was inversely correlated with thickness (r = -0.805, P = 0.0001). A model suggesting the possible changes induced by cagA+ infection is propose...Continue Reading

Citations

Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Mohmmad HaidariFarid Najaf
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ellen J BeswickVictor E Reyes
May 24, 2006·World Journal of Gastroenterology : WJG·Kazunari MurakamiToshio Fujioka
Jan 8, 2020·International Journal of Molecular Sciences·Bin LiuNiannian Li

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