The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study

Osteoarthritis and Cartilage
Staffan LarssonL S Lohmander

Abstract

To investigate whether change in concentrations over time of aggrecanase generated ARGS-aggrecan in synovial fluid (SF ARGS) associates with progression of radiographic knee osteoarthritis (OA) and patient-reported outcome in subjects with previous meniscectomy. We studied 141 subjects at two time points after meniscectomy. Time point A was on average 18 years after meniscectomy, time point B was on average 7.5 years later; 74 subjects had SF available from both examinations. We measured SF ARGS by an electrochemiluminescence immunoassay, graded radiographic features of tibiofemoral or patellofemoral OA according to the Osteoarthritis Research Society International (OARSI) atlas, and scored patient-reported outcomes using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Using logistic regression (adjusted for age, gender, body mass index, time between examinations, and SF ARGS at first examination) we assessed associations between change in SF ARGS between first and second examinations and progression of radiographic OA and KOOS. In subjects with decreasing SF ARGS between examinations, the likelihood of loss of joint space and worsening of KOOS pain between examinations was increased 6- and 4-fold respectively compared...Continue Reading

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Citations

Jul 31, 2013·Annals of the Rheumatic Diseases·M LotzJ-Y Reginster
Feb 19, 2014·Postgraduate Medical Journal·M LotzJ-Y Reginster
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Jul 1, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Timothy W TourvilleBruce D Beynnon
Dec 24, 2013·Osteoarthritis and Cartilage·S LarssonA Struglics
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Oct 27, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Scott M WasilkoBruce D Beynnon
Jun 16, 2018·Journal of Experimental Orthopaedics·Ioannis PengasLior Laver

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