The Association Between Circulating Levels of miRNA-181a and Pancreatic Beta Cells Dysfunction via SMAD7 in Type 1 Diabetic Children and Adolescents

Journal of Clinical Laboratory Analysis
Enas Samir Nabih, Nevine Gamal Andrawes

Abstract

miRNA-181a has been implicated in autoimmunity and apoptosis. Therefore, this study was conducted to explore its possible role in pancreatic beta-cells dysfunction. miRNA-181a expression was evaluated by real-time PCR in serum of 40 type 1 diabetic children and adolescents and 40 age- and gender-matched healthy controls. miRNA-181a expression was significantly higher in diabetic children and adolescents and it was negatively correlated to fasting C-peptide and SMAD7 levels. miRNA-181a appears to play a potential role in pancreatic beta-cells dysfunction via SMAD7.

References

Oct 27, 2001·Science·R C Lee, V Ambros
Jun 10, 2005·Nature·Jun LuTodd R Golub
Dec 23, 2006·Antioxidants & Redox Signaling·Hideaki KanetoYoshimitsu Yamasaki
Jul 4, 2007·Circulation·Thomas ThumJohann Bauersachs
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
Mar 5, 2009·PloS One·Nora KlötingMatthias Blüher
Apr 9, 2009·Acta Biochimica Et Biophysica Sinica·Xiaohua YanYeguang Chen
Mar 11, 2010·Advances in Experimental Medicine and Biology·James D Johnson, Dan S Luciani
Jan 21, 2011·Physiological Reviews·Tom L van BelleMatthias G von Herrath
Oct 4, 2011·Cell·Hao ZhuGeorge Q Daley
Jul 10, 2012·Molecular Aspects of Medicine·Marcos Malumbres
Jan 30, 2013·PloS One·Christos ArgyropoulosJohn Johnson
Mar 22, 2014·Pediatric Diabetes·Dana E VanBuecken, Carla J Greenbaum

❮ Previous
Next ❯

Citations

Mar 20, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Chenggui MiaoYanxi Fang
Mar 24, 2020·The Journal of Obstetrics and Gynaecology Research·Yuping XiaoWeiqun Wang
Feb 11, 2021·European Journal of Clinical Investigation·Kosmas MargaritisAssimina Galli-Tsinopoulou
Aug 26, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Lian YiWei-Jun Qian
Apr 5, 2021·Chinese Medical Journal·Jing ZhangCong-Yi Wang
Aug 19, 2021·Antioxidants & Redox Signaling·Silvia GaravelliPaola de Candia
Aug 27, 2021·Bioorganic & Medicinal Chemistry Letters·Xue LiGang Chen
Oct 23, 2020·Current Pharmaceutical Design·Giuseppe LassandroPaola Giordano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.