The association between cocaine use and treatment outcomes in patients receiving office-based buprenorphine/naloxone for the treatment of opioid dependence.

The American Journal on Addictions
Lynn E SullivanDavid A Fiellin

Abstract

Cocaine use in patients receiving methadone is associated with worse treatment outcomes. The association between cocaine use and office-based buprenorphine/naloxone treatment outcomes is not known. We evaluated the association between baseline and in-treatment cocaine use, treatment retention, and urine toxicology results in 162 patients enrolled in a 24-week trial of primary care office-based buprenorphine/naloxone maintenance. Patients with baseline cocaine metabolite-negative urine toxicology tests compared with those with cocaine metabolite-positive tests had more mean weeks of treatment retention (18.3 vs. 15.8, p = .04), a greater percentage completed 24 weeks of treatment (50% vs. 33%, p = .04) and had a greater percentage of opioid-negative urines (47% vs. 34%, p = .02). Patients with in-treatment cocaine metabolite-negative urine toxicology tests compared with cocaine metabolite-positive patients had more mean weeks of treatment retention (19.0 vs. 16.5, p = .003), a greater percentage completed 24 weeks of treatment (60% vs. 30%, p < .001), and had a greater percentage of opioid-negative urines (51% vs. 35%, p = .001). We conclude that both baseline and in-treatment cocaine use is associated with worse treatment outco...Continue Reading

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Citations

Mar 14, 2013·Journal of Addictive Diseases·Anne M NeumannMohammadreza Azadfard
Nov 6, 2013·Journal of Addiction Medicine·E Jennifer EdelmanLynn E Fiellin
Jun 24, 2014·Journal of Substance Abuse Treatment·Zev Schuman-OlivierMark J Albanese
Apr 10, 2013·Journal of Substance Abuse Treatment·Jan GryczynskiRobert P Schwartz
Sep 4, 2012·Journal of Substance Abuse Treatment·Jeanette M TetraultLynn E Fiellin
Apr 5, 2011·Journal of Substance Abuse Treatment·Jeffrey D BaxterLobat Hashemi
Jun 26, 2013·The American Journal on Addictions·Chinazo O CunninghamNancy L Sohler
Feb 6, 2010·The American Journal on Addictions·Elinore F McCance-KatzDavid E Moody
Dec 7, 2014·Journal of Substance Abuse Treatment·Jeanette M TetraultLynn E Fiellin
Apr 6, 2017·Journal of Addiction Medicine·John R Brooklyn, Stacey C Sigmon
Feb 23, 2019·Critical Reviews in Toxicology·Andrea G BarthwellKenneth Egli
Feb 19, 2010·The American Journal on Addictions·Roger D WeissWalter Ling
Nov 22, 2018·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·XuYi WangWei Hao
Jun 22, 2017·Addiction Biology·Marsida KallupiRoberto Ciccocioppo
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Jun 13, 2021·Journal of Substance Abuse Treatment·Thomas FatkinZev Schuman-Olivier

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