Abstract
Animal models suggest that impaired leptin production, or leptin resistance despite increased leptin levels, may contribute to depression. The link between leptin and depression could be mediated by obesity, which is more common in depression and increases leptin production. We administered the Beck Depression Inventory-II (BDI-II) to 537 participants (mean [standard deviation (SD)] age = 51 [9] years; female, 61%) enrolled in the Morehouse and Emory Team up to Eliminate Health Disparities (META-Health) study. Leptin levels were examined as continuous log-transformed values. Participants with moderate to severe depression had higher levels of leptin (median [interquartile range] 37.7 [17.6-64.9] ng/mL) than those with mild depression (22.9 [7.0-57.9] ng/mL) or minimal to no depression (19.8 ng/mL [7.8-39.1], p = .003). Participants with moderate to severe depression had higher body mass index (BMI) than those with mild or minimal depression (mean [SD] = 33 [8] versus 31 [9] versus 29 [7] kg/m(2), p = .001). After multivariate adjustment for age, sex, race, smoking status, hypertension, diabetes, blood pressure, lipids, and C-reactive protein, the BDI-II score remained a significant predictor of leptin levels (β = 0.093, p = .01...Continue Reading
References
Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M DeuschleI Heuser
Dec 9, 1998·Journal of Psychiatric Research·I A AntonijevicA Steiger
Jun 8, 1999·Cellular Immunology·J Santos-AlvarezV Sánchez-Margalet
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·J M NicolásR Estruch
May 8, 2001·Neuroendocrinology·T KrausT Pollmächer
Dec 14, 2002·The American Journal of Cardiology·Gregory E MillerWilliam A Banks
Jul 2, 2003·Brain, Behavior, and Immunity·Gregory E MillerWilliam A Banks
Dec 4, 2003·American Journal of Epidemiology·Chiadi U OnyikeWilliam W Eaton
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Kristopher J Preacher, Andrew F Hayes
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giuseppe MatareseChristos S Mantzoros
Apr 28, 2005·Nature Neuroscience·Heike Münzberg, Martin G Myers
Jul 5, 2005·Lancet·Jean L Chan, Christos S Mantzoros
Oct 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sang Eun KimMyung Chul Lee
Nov 23, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M HeoM S Faith
Dec 6, 2005·Journal of Affective Disorders·Guey-Mei JowChun-Lan Chen
Jan 13, 2006·Psychiatry and Clinical Neurosciences·Omer GeciciBilal Ustundag
Jan 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xin-Yun LuWei Zhang
Mar 30, 2006·Pharmacology·Chandrashekhar DeshpandeS K Kulkarni
Jul 19, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ting-Kai Li, Bernice Porjesz
Aug 2, 2006·Molecular Psychiatry·S R BornsteinJ Licinio
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Aoife M Brennan, Christos S Mantzoros
Sep 16, 2006·Neuroscience Letters·Roberto LeoFrancesco Romeo
Oct 19, 2006·Neuroscience·J BroussardB Givens
Nov 28, 2006·Pharmacology, Biochemistry, and Behavior·George MamalakisAnthony Kafatos
Jun 9, 2007·Neuropsychobiology·Hubertus HimmerichManfred Uhr
Aug 31, 2007·Journal of Affective Disorders·Julie A PascoMichael Berk
Nov 21, 2007·Journal of the American College of Cardiology·Viola VaccarinoUNKNOWN National Heart, Lung, and Blood Institute
Jan 3, 2008·PloS One·An PanXu Lin
Aug 22, 2009·Acta Psychiatrica Scandinavica·S M LehtoJ Hintikka
Apr 28, 2011·Endocrinology·Nobuko YamadaKazuwa Nakao
May 21, 2011·Psychosomatic Medicine·Melanie L Zupancic, Aman Mahajan
Jul 1, 2011·Psychosomatic Medicine·Alanna Amyre MorrisViola Vaccarino
Citations
Oct 30, 2013·International Journal of Rheumatic Diseases·Shereen M OlamaMohammad El-Arman
Nov 16, 2013·BMC Medicine·Almudena Sánchez-VillegasLluis Serra-Majem
Jul 26, 2014·PloS One·Yan-tao LiWen-li Zhao
Jan 26, 2013·Diabetes Care·Carol KanKhalida Ismail
Feb 28, 2015·Biological Psychology·Mustafa al'AbsiSharon Allen
Mar 19, 2014·Psychoneuroendocrinology·Yuri MilaneschiLuigi Ferrucci
Oct 16, 2013·Molecular Psychiatry·A Aguilar-VallesG N Luheshi
Apr 26, 2014·Nutrition Journal·Aurora Perez-CornagoM Angeles Zulet
Feb 26, 2013·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Diana A ChirinosNeil Schneiderman
Feb 11, 2016·Journal of Child and Adolescent Psychopharmacology·Özgür Korhan TunçelBirşen Bilgici
Jan 30, 2015·Peptides·Joana Pereira de Carvalho-FerreiraAna R Dâmaso
Jun 3, 2015·Psychiatry Research·Chinedu C Ubani, Jian Zhang
Jan 23, 2014·Psychiatry and Clinical Neurosciences·Hiromi Yoshida-KomiyaShin-Ichi Niwa
Sep 20, 2015·Psychopharmacology·Natsuki KurosawaKenjiro Seki
Jul 2, 2015·Pharmacology & Therapeutics·Yutaka Nakagawa, Kenji Chiba
Feb 13, 2014·Physiology & Behavior·Claudia A GrilloLawrence P Reagan
May 28, 2014·Journal of Chemical Neuroanatomy·Jeanette C Valleau, Elinor L Sullivan
Apr 27, 2013·Behavioural Brain Research·Jin-Fang GeJiang-Ning Zhou
Jan 22, 2015·Maturitas·Juan Enrique Blümel
Dec 10, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Aurora Perez-CornagoM Angeles Zulet
Oct 1, 2014·Journal of Behavioral Medicine·Diana A ChirinosJulio A Chirinos
Jun 14, 2016·Archives of Women's Mental Health·Chunfeng ChenYizhi Zheng
Oct 16, 2016·Scientific Reports·Jin Ling YangRoger Cm Ho
Mar 2, 2018·Acta Diabetologica·Yu Ming SangYi Jun Zhu
Dec 1, 2017·PloS One·M'Balu WebbKamlesh Khunti
Aug 17, 2018·Cognitive, Affective & Behavioral Neuroscience·Carla M PatistJohn P Headrick
Jan 25, 2019·Psychosomatic Medicine·Gwen TindulaNina Holland
Dec 19, 2018·Journal of Tropical Pediatrics·Ehsaneh TaheriRoya Kelishadi
Sep 22, 2018·Nutrients·Adela M NavarroEstefanía Toledo
Nov 9, 2018·Frontiers in Psychiatry·Rachael Horne, Jane A Foster
Jul 30, 2019·Frontiers in Neuroscience·Abdulrahman A A AmerFei Wang
Jan 31, 2015·ANS. Advances in Nursing Science·Ingrid Ruud Knutsen
Apr 5, 2018·Frontiers in Neurology·Pierre EllulDavid Klatzmann
Oct 28, 2018·Cell Death & Disease·Tongtong GeBingjin Li
Oct 8, 2020·BMC Psychiatry·Yu Ming SangYue Hua Zhu
May 29, 2021·International Journal of Tryptophan Research : IJTR·Johann SteinerGregory F Oxenkrug
Mar 18, 2019·Psychiatry Research·Jessica G MillsSusan J Thomas