The association between diabetes and breast cancer stage at diagnosis: a population-based study

Breast Cancer Research and Treatment
L L LipscombeLawrence Paszat

Abstract

Women with diabetes have higher breast cancer incidence and mortality. The purpose of this study was to examine the impact of diabetes on stage at breast cancer diagnosis, as a possible reason for their higher mortality. Using population-based health databases from Ontario, Canada, this retrospective cohort study examined stage at diagnosis (II, III, or IV vs I) among women aged 20-105 years who were newly diagnosed with invasive breast cancer between 2007 and 2012. We compared those with diabetes to those without diabetes. Diabetes was defined based on medical records using a validated algorithm. Among 38,407 women with breast cancer, 6115 (15.9 %) women had diabetes. Breast cancer patients with diabetes were significantly more likely to present with advanced-stage breast cancer than those without diabetes. After adjustment for mammograms and other covariates, diabetes was associated with a significantly increased risk of Stage II [adjusted odds ratio (aOR) 1.14, 95 % confidence interval (CI) 1.07, 1.22], Stage III (aOR 1.21, 95 % CI 1.11, 1.33), and Stage IV (aOR 1.16, 95 % CI 1.01, 1.33) versus Stage I breast cancer. Women with diabetes had a higher risk of lymph node metastases (aOR 1.16, 95 % CI 1.06, 1.27) and tumors with...Continue Reading

References

Mar 17, 2001·JAMA : the Journal of the American Medical Association·R YancikJ W Yates
Nov 28, 2001·Diabetes Care·T J BeckmanV S Pankratz
Oct 21, 2004·Journal of the National Cancer Institute·Stephen H TaplinWilliam E Barlow
Jan 19, 2005·Medical Care·Steven T FlemingKun Chen
Oct 12, 2005·Archives of Internal Medicine·Lorraine L LipscombeGillian L Booth
Jan 13, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L V van de Poll-FranseJ W W Coebergh
Jan 19, 2007·International Journal of Cancer. Journal International Du Cancer·Lonneke V van de Poll-FranseHarm R Haak
Mar 14, 2007·Diabetes Care·A Marshall McBean, Xinhua Yu
Jul 31, 2007·Breast Cancer Research and Treatment·Lorraine L LipscombeJanet E Hux
Nov 27, 2008·Journal of the National Cancer Institute·Karla KerlikowskeDiana S M Buist
Dec 18, 2008·JAMA : the Journal of the American Medical Association·Bethany B BaroneFrederick L Brancati
Dec 18, 2008·Journal of General Internal Medicine·Guixiang ZhaoAli H Mokdad
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomasz P SrokowskiSharon H Giordano
Dec 17, 2009·Nursing Research·Janet G MarshallDiane B McNaughton
Jun 16, 2010·Diabetologia·U Smith, E A M Gale
Nov 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda LeeMonika K Krzyzanowska
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly S PeairsAntonio C Wolff
Dec 15, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Philip D Austin, Sarah E Henderson
Mar 4, 2011·The New England Journal of Medicine·Sreenivasa Rao Kondapally SeshasaiUNKNOWN Emerging Risk Factors Collaboration
Apr 2, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hiroshi NotoMitsuhiko Noda
Apr 6, 2012·Diabetologia·A G RenehanUNKNOWN Diabetes and Cancer Research Consortium
Mar 5, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·W ChanL L Lipscombe
Sep 24, 2014·JAMA : the Journal of the American Medical Association·Linda S GeissEdward W Gregg
Jan 15, 2015·JAMA : the Journal of the American Medical Association·Javaid IqbalSteven A Narod

❮ Previous
Next ❯

Citations

Sep 4, 2015·The Nursing Clinics of North America·Costellia H Talley, Karen Patricia Williams
Jul 15, 2015·Journal of Diabetes Research·Chin-Hsiao Tseng
May 14, 2016·The British Journal of Nutrition·Khemayanto HidayatLi-Qiang Qin
Oct 7, 2016·Cancer Medicine·Syed Yaser HabeebLorraine L Lipscombe
May 26, 2017·Expert Opinion on Investigational Drugs·Rui GaoWei Xu
Jan 21, 2018·Diabetes Care·Iliana C LegaLorraine L Lipscombe
Jan 11, 2018·International Journal of Cancer. Journal International Du Cancer·M O MurtoT J Murtola
Oct 28, 2018·Breast Cancer Research and Treatment·Gertraud MaskarinecLoïc Le Marchand
Nov 14, 2019·Endocrine Reviews·Iliana C Lega, Lorraine L Lipscombe
Jun 14, 2019·Oncotarget·István GyurjánAndreas Weinhäusel
Dec 31, 2016·Oncotarget·Rachel GoldbergMichael Elkin
Nov 7, 2018·World Journal of Clinical Cases·Amitabha Ray
Jul 6, 2019·Journal of Diabetes and Metabolic Disorders·Hadith RastadKamran Yazdani
Apr 28, 2017·World Journal of Surgery·Akihiko OkamuraShinji Mine
Jun 18, 2020·World Journal of Diabetes·Mina WangZehuan Liao
Feb 23, 2017·World Journal of Surgical Oncology·Malte KrönigCordula Annette Jilg
Sep 26, 2020·Journal of General Internal Medicine·Michelle DooseJennifer Tsui
Nov 20, 2020·Expert Opinion on Drug Safety·Shahariar Mohammed FahimChiahung Chou
Apr 6, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Grace H TangPaola Muti
Jan 15, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Catherine SchairerEric A Engels
Feb 20, 2021·Frontiers in Oncology·Tiffany ScullyEmily Jane Gallagher
Apr 13, 2021·Oncology & Hematology Review·Kristy A BrownPanagiota Andreopoulou
Aug 6, 2021·International Journal of General Medicine·Jingtai ChenYanchun Gao
Nov 21, 2021·Cancer Causes & Control : CCC·Dominika BhatiaLorraine L Lipscombe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
J J KellerH-C Lin
© 2021 Meta ULC. All rights reserved