The association between dietary saturated fatty acids and ischemic heart disease depends on the type and source of fatty acid in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort

The American Journal of Clinical Nutrition
Jaike PraagmanYvonne T van der Schouw

Abstract

The association between saturated fatty acid (SFA) intake and ischemic heart disease (IHD) risk is debated. We sought to investigate whether dietary SFAs were associated with IHD risk and whether associations depended on 1) the substituting macronutrient, 2) the carbon chain length of SFAs, and 3) the SFA food source. Baseline (1993-1997) SFA intake was measured with a food-frequency questionnaire among 35,597 participants from the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort. IHD risks were estimated with multivariable Cox regression for the substitution of SFAs with other macronutrients and for higher intakes of total SFAs, individual SFAs, and SFAs from different food sources. During 12 y of follow-up, 1807 IHD events occurred. Total SFA intake was associated with a lower IHD risk (HR per 5% of energy: 0.83; 95% CI: 0.74, 0.93). Substituting SFAs with animal protein, cis monounsaturated fatty acids, polyunsaturated fatty acids (PUFAs), or carbohydrates was significantly associated with higher IHD risks (HR per 5% of energy: 1.27-1.37). Slightly lower IHD risks were observed for higher intakes of the sum of butyric (4:0) through capric (10:0) acid (HRSD: 0.93; 95% CI: 0.89, 0.99), myristic a...Continue Reading

References

Apr 1, 1992·Journal of Epidemiology and Community Health·R M HeringsG Nap
Nov 1, 1965·The American Journal of Clinical Nutrition·D M HegstedF J Stare
Apr 1, 1997·The American Journal of Clinical Nutrition·W C WillettL H Kushi
Jan 1, 1997·International Journal of Epidemiology·M C OckéD Kromhout
Dec 3, 1999·The American Journal of Clinical Nutrition·F B HuW C Willett
Jun 26, 2002·The American Journal of Clinical Nutrition·Kaye Foster-PowellJanette C Brand-Miller
May 11, 1957·Lancet·E H AHRENSM L PETERSON
Feb 13, 2009·The American Journal of Clinical Nutrition·Marianne U JakobsenAlberto Ascherio
Jun 2, 2009·International Journal of Epidemiology·Joline W J BeulensH Bas Bueno-de-Mesquita
Jan 15, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Apr 26, 2011·Journal of the American Dietetic Association·Dariush Mozaffarian
Jul 5, 2012·The American Journal of Clinical Nutrition·Marcia C de Oliveira OttoJennifer A Nettleton
Apr 12, 2013·European Journal of Preventive Cardiology·Gerben HulseggeW M Monique Verschuren
Apr 12, 2014·Annals of Internal Medicine·Rajiv ChowdhuryEmanuele Di Angelantonio

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Citations

May 26, 2016·Current Atherosclerosis Reports·Peter J Joris, Ronald P Mensink
Nov 5, 2015·PloS One·Benjamin Leon BodirskyHermann Lotze-Campen
Sep 27, 2012·Brain, Behavior, and Immunity·Janice K Kiecolt-GlaserElizabeth Blackburn
Sep 22, 2016·Current Cardiology Reports·Peter L ZockGerard Hornstra
Jan 6, 2017·British Journal of Sports Medicine·Timothy David Noakes, Johann Windt
Jan 27, 2017·Annals of Nutrition & Metabolism·Joyce A NettletonGerard Hornstra
Jan 1, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael GoettelMax Scherer
Jan 10, 2018·Journal of the American College of Nutrition·Mark HoustonMimi Guarneri
Oct 24, 2017·Food & Nutrition Research·Karianne SvendsenKjetil Retterstøl
Apr 11, 2018·Public Health Nutrition·Magdalena Makarewicz-WujecMałgorzata Kozłowska-Wojciechowska
Aug 8, 2018·Current Nutrition Reports·Victoria M Gershuni
Jul 16, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jaike PraagmanOscar H Franco
Jan 26, 2018·International Journal of Food Sciences and Nutrition·Emiliano KakisuJuan Fuentes
Feb 11, 2018·Scientific Reports·Flavia SpreaficoAlberto Dávalos
May 20, 2018·Journal of the American Society of Nephrology : JASN·Alexander G Logan, Andrew Mente
Sep 28, 2018·The Open Rheumatology Journal·Meriam MessediFatma Ayedi
Jun 25, 2017·Annual Review of Nutrition·Dong D Wang, Frank B Hu
Nov 16, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N R W GeikerA Astrup
Jul 9, 2016·Current Opinion in Lipidology·Patty W Siri-Tarino, Ronald M Krauss
Mar 28, 2017·Journal of Dairy Science·R Lordan, I Zabetakis
Feb 15, 2017·International Journal of Food Science·Marta Del PuertoAli Saadoun
Nov 21, 2017·Therapeutic Advances in Cardiovascular Disease·Mark Houston
Jan 5, 2019·The Journal of Nutrition·Pan ZhuangJingjing Jiao
Jun 12, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Andrea Poli
Jul 25, 2017·Current Atherosclerosis Reports·Silvio Zaina, Gertrud Lund
Jul 28, 2019·BMJ : British Medical Journal·Jordi MerinoJose C Florez
Jul 25, 2018·Food & Nutrition Research·Chenyan LvHuanling Yu
Sep 1, 2018·European Journal of Nutrition·Linda E T VissersIvonne Sluijs
Oct 4, 2018·Genes & Nutrition·Linda H MüngerGiulia Praticò
Nov 13, 2019·European Journal of Clinical Nutrition·Jean-Marie BardUNKNOWN INNOVALAIT Study group
Aug 24, 2020·Reviews in Endocrine & Metabolic Disorders·Ramon Estruch, Emilio Ros
Mar 28, 2018·The Journal of Nutrition, Health & Aging·S SantiagoM A Martínez-González

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