The Association Between Endocan Levels and Subclinical Atherosclerosis in Patients With Type 2 Diabetes Mellitus

The American Journal of the Medical Sciences
Yaya LvJinxing Quan

Abstract

Proinflammatory conditions induced by circulating factors in diabetes play a pivotal role in endothelial dysfunction and related vascular complications. Endothelial cell-specific molecule-1 or endocan is a dermatan sulfate proteoglycan secreted primarily by the vascular endothelium. Although endocan has been shown to be a potential biomarker in coronary heart disease, its role in the pathogenesis of atherosclerosis (AS) in diabetes remains unclear. In this study, we investigated the correlation between serum endocan levels and subclinical AS in patients with type 2 diabetes mellitus (T2DM). Patients (n = 69) with T2DM were included. All the patients were stratified based on the absence (n = 42) or presence (n = 27) of subclinical AS. Healthy subjects (n = 28) served as controls. Serum levels of endocan, fasting blood glucose, glycosylated hemoglobin A1, high-sensitivity C-reactive protein and carotid intima-media thickness (cIMT) were measured. Endocan levels were significantly elevated in both the T2DM (0.89 ± 0.28ng/mL) and T2DM with subclinical AS (1.20 ± 0.33ng/mL) groups relative to the control group (0.68 ± 0.24ng/mL) (P < 0.05 for all). Endocan levels were also positively correlated with glycosylated hemoglobin A1, fasti...Continue Reading

Citations

Jul 23, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ayşe AnıkAhmet Anık
Feb 23, 2020·Angiology·Ana Rita LeiteAdelino Leite-Moreira
Jul 18, 2020·Cardiology Research and Practice·L TurgunovaL Akhmaltdinova
Mar 10, 2018·Journal of Cardiovascular Development and Disease·Roshan Kumar MahatVedika Rathore
Jun 9, 2020·Frontiers in Immunology·Ariane R PessentheinerPhilip L S M Gordts
Dec 16, 2020·The Clinical Respiratory Journal·Erdal İnNevin İlhan
Nov 18, 2019·International Journal of Biological Macromolecules·Sarwareddy Kartik KumarKrishna Priya Mani
Jul 28, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·João BessaTeresa Sousa
May 1, 2021·Current Opinion in Cardiology·Sevket BaltaDimitri P Mikhailidis
Jun 10, 2021·Therapeutic Advances in Chronic Disease·Laila M SheriefMarwa Zakaria

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