The association between follicular fluid levels of cathepsin B, relaxin or AMH with clinical pregnancy rates in infertile patients

European Journal of Obstetrics, Gynecology, and Reproductive Biology
E BastuFaruk Buyru

Abstract

The aim of this study was to investigate the relationship of cathepsin B, relaxin and anti-Mullerian hormone (AMH) in follicular fluid (FF) with pregnancy rates in infertility patients. Seventy-nine infertile couples who underwent ICSI were included in the study. The FF levels of cathepsin B, relaxin and AMH were measured using ELISA kits. The FF cathepsin B levels were statistically higher in pregnant patients compared with non-pregnant patients (0.20±0.13 versus 0.13±0.03; P<0.001). There were statistically significant differences in the total number of oocytes (10.00±6.85 versus 5.96±3.94); the mean number of M2 oocytes (8.65±5.63 versus 4.58±3.36) between the pregnant and non-pregnant patients (P<0.05). There were no significant correlations between pregnancy rates and relaxin and AMH (P>0.05). The area under the curve of cathepsin B for prediction of pregnancy was 0.662 (p=0.024, 95% Confidence Interval 0.528-0.797). This study demonstrated that increased level of cathepsin B in FF significantly correlates with a better chance of clinical pregnancy. Further studies are needed to clarify the role of cathepsin B in the reproductive process of humans.

References

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Jan 22, 2011·Reproductive Biology and Endocrinology : RB&E·Jean M FeugangPeter L Ryan
May 10, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E BastuF Buyru
Jul 31, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·A Z BalboulaM Takahashi

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Citations

Dec 10, 2016·British Journal of Pharmacology·Richard IvellRavinder Anand-Ivell
May 9, 2019·Journal of Assisted Reproduction and Genetics·Ozguc TakmazErcan Bastu
Jun 10, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ho Yeon Kim, Hye Sung Baek
Sep 15, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·L WitzkeV Ziller

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