The association between frailty and MRI features of cerebral small vessel disease

Scientific Reports
Ilse M J KantBioCog Consortium

Abstract

Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between frailty and MRI features of cerebral small vessel disease in a group of non-demented older individuals. We included 170 participants who were classified as frail (n = 30), pre-frail (n = 85) or non-frail (n = 55). The association of frailty and white matter hyperintensity volume and shape features, lacunar infarcts and cerebral perfusion was investigated by regression analyses adjusted for age and sex. Frail and pre-frail participants were older, more often female and showed higher white matter hyperintensity volume (0.69 [95%-CI 0.08 to 1.31], p = 0.03 respectively 0.43 [95%-CI: 0.04 to 0.82], p = 0.03) compared to non-frail participants. Frail participants showed a non-significant trend, and pre-frail participants showed a more complex shape of white matter hyperintensities (concavity index: 0.04 [95%-CI: 0.03 to 0.08], p = 0.03; fractal dimensions: 0.07 [95%-CI: 0.00 to 0.15], p = 0.05) compared to non-frail participants. No between group differences were found in gray matter perfusion or in the presence of la...Continue Reading

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Citations

Apr 2, 2020·Fluids and Barriers of the CNS·Afroditi D LalouZofia Czosnyka
Aug 1, 2020·Frontiers in Medicine·Isabel Suárez-MéndezLeocadio Rodríguez-Mañas
Nov 17, 2020·Frontiers in Medicine·Qu TianLuigi Ferrucci
Nov 28, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Wan-Hsuan LuUNKNOWN MAPT/DSA Group
Feb 2, 2021·Frontiers in Medicine·Nan JordanPaul Yates
Mar 2, 2021·Neurobiology of Aging·Ilse M J KantUNKNOWN BioCog consortium
Mar 9, 2021·Frontiers in Aging Neuroscience·Isabel Suárez-MéndezLeocadio Rodríguez-Mañas
Nov 30, 2019·Journal of the American Medical Directors Association·Ebrahim Bani HassanGustavo Duque

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Software Mentioned

BioCog
Matlab
SPM8

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