The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide

Atherosclerosis
C D ByrneC N Hales

Abstract

To investigate whether there were associations between the free fatty acid (FFA) response during a fat tolerance test and changes in concentrations of triglyceride-rich lipoproteins 57 healthy Caucasian men between 57 and 70 years of age underwent a fat tolerance test lasting 8 h. FFA concentrations initially decreased from 0.75 +/- 0.03 to 0.64 +/- 0.03 mmol/l at 2 h and thereafter increased to 1.2 +/- 0.04 mmol/l at 8 h. Maximum FFA concentration was the only significant determinant of 8 h triglyceride-rich lipoprotein (TGRLP) concentrations (pooled chylomicron and VLDL fractions d < 1.006) (TGRLP-TG r = 0.33, P = 0.012; TGRLP apo B r = 0.37, P = 0.004; TGRLP cholesterol r = 0.38, P = 0.004). The strength of the association between FFA and TGRLP was affected by the apo B signal peptide genotype. Only in individuals who were homozygous for the 27 amino acid (SP27 or I) allele of the apo B signal peptide were there significant associations between maximum FFA concentration quartile and 8 h TGRLP concentration (P value for linear trend = 0.025). In this genotype group there were lower HDL cholesterol concentrations (1.16 mmol/l compared to 1.38 mmol/l in subjects either heterozygous or homozygous for the SP24 [D] allele; P = 0.0...Continue Reading

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Citations

Apr 27, 2001·Biochemical and Biophysical Research Communications·F BenhiziaP J Talmud
Dec 21, 2000·Current Atherosclerosis Reports·W PatschJ R Patsch
Aug 21, 2007·The British Journal of Nutrition·José Lopez-MirandaDenis Lairon
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May 27, 1999·The Proceedings of the Nutrition Society·J M Ordovas
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Jun 9, 2005·The Journal of Biological Chemistry·Philippa J TalmudSteve E Humphries
Feb 27, 2020·PloS One·Paul T Williams

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