The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies

NPJ Schizophrenia
Julia H HarariCelso Arango

Abstract

Evidence suggests that genetic variation might influence structural brain alterations in psychotic disorders. Longitudinal genetic neuroimaging (G-NI) studies are designed to assess the association between genetic variants, disease progression and brain changes. There is a paucity of reviews of longitudinal G-NI studies in psychotic disorders. A systematic search of PubMed from inception until November 2016 was conducted to identify longitudinal G-NI studies examining the link between Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI)-based brain measurements and specific gene variants (SNPs, microsatellites, haplotypes) in patients with psychosis. Eleven studies examined seven genes: BDNF, COMT, NRG1, DISC1, CNR1, GAD1, and G72. Eight of these studies reported at least one association between a specific gene variant and longitudinal structural brain changes. Genetic variants associated with longitudinal brain volume or cortical thickness loss included a 4-marker haplotype in G72, a microsatellite and a SNP in NRG1, and individual SNPs in DISC1, CNR1, BDNF, COMT and GAD1. Associations between genotype and progressive brain changes were most frequently observed in frontal regions, with five studies reporting sig...Continue Reading

References

Feb 20, 1999·Archives of General Psychiatry·A G CardnoR M Murray
Jan 23, 2002·Molecular Psychiatry·M MallatV Moura Neto
Apr 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·A C D JamesD M Smith
Oct 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ilya ChumakovJohn Realson
May 27, 2003·Schizophrenia Research·Audrey KellerJudith L Rapoport
Jun 11, 2003·Annals of Medicine·John J McGrathDarryl W Eyles
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Jul 21, 2004·Molecular Psychiatry·P J Harrison, D R Weinberger
Apr 6, 2005·Archives of General Psychiatry·Jeffrey A LiebermanUNKNOWN HGDH Study Group
Apr 4, 2006·Biological Psychiatry·Sevilla D Detera-Wadleigh, Francis J McMahon
Jun 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·R Grant SteenJeffrey A Lieberman
Apr 18, 2007·Human Brain Mapping·Carrie E BeardenTyrone D Cannon
Mar 12, 2008·Current Opinion in Psychiatry·Neeltje E van HarenRené S Kahn
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul Eisenberg, Karen Faith Berman
Sep 18, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sarah M HartzThomas H Wassink
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kenji NakataJoel E Kleinman
Oct 19, 2010·Biological Psychiatry·Petra HabetsUNKNOWN Genetic Risk and Outcome of Psychosis (G.R.O.U.P)
Oct 27, 2010·Neuroscience and Biobehavioral Reviews·Byron K Y Bitanihirwe, Tsung-Ung W Woo
Jan 21, 2011·Current Opinion in Psychiatry·Peter F BuckleyKristy R Howell
Jun 21, 2011·Journal of Neural Transmission·Yoanna Arlina KurnianingsihKang Sim
Apr 11, 2012·Molecular Psychiatry·J L RapoportN Gogtay
Oct 9, 2012·Neuron·Pablo E CastilloYuki Hashimotodani
Jan 10, 2013·Neuroscience·C W HoltzmanE F Walker
Feb 19, 2013·Biological Psychiatry·Anna M Fineberg, Lauren M Ellman

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