The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Diabetologia
Mengge ZhouDong Zhao

Abstract

Previous studies have suggested a possible connection between Helicobacter pylori (H. pylori) infection and diabetes risk. However, prospective studies examining direct associations between these two factors are relatively lacking. In this prospective cohort study, we aimed to evaluate the association between H. pylori infection and risk of developing diabetes. We performed a population-based prospective study, recruiting participants aged 45-74 years and without diabetes from the Chinese Multi-provincial Cohort Study in 2002, with a 10 year follow-up to investigate development of diabetes. H. pylori serostatus was determined by measuring serum H. pylori antibodies. H. pylori seropositivity was defined as the antibody concentration ≥ 10 U/ml. To examine the association between H. pylori seropositivity and diabetes risk, modified Poisson regression was performed. Of 2085 participants without diabetes, 1208 (57.9%) were H. pylori seropositive in 2002. After multivariate adjustment of possible diabetes risk factors, H. pylori seropositivity was associated with lower risk of diabetes (RR 0.78 [95% CI 0.63, 0.97], p = 0.022). Of the 1275 participants with H. pylori antibody measurements in both 2002 and 2007, 677 (53.1%) were persis...Continue Reading

References

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Citations

Mar 31, 2018·Minerva gastroenterologica e dietologica·Gianenrico RizzattiAntonio Gasbarrini
Sep 12, 2018·Helicobacter·Danute Ražuka-EbelaFrancesco Franceschi
Jan 22, 2019·Journal of Diabetes Investigation·Masayuki KatoHirohito Sone
Jul 16, 2019·Minerva endocrinologica·Marina ValenzanoGiorgio Grassi

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Methods Mentioned

BETA
antibody assay
serum collection

Software Mentioned

SAS

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