PMID: 9432358Jul 1, 1997Paper

The association between Helicobacter pylori infection and ischemic heart disease: facts or fancy?

Helicobacter
F Parente, G Bianchi Porro

Abstract

Helicobacter pylori infection has been associated recently with an increased risk of developing ischemic heart disease. We critically reviewed the literature on the association between Helicobacter and ischemic heart disease. It has been suggested that a persistent low-grade inflammatory response resulting from chronic gastritis caused by H. pylori may increase the concentration of certain coagulation factors, such as fibrinogen, which are predictors of ischemic heart disease. After the appearance of the first studies indicating a moderately strong association, other researchers have investigated the potential association between these two conditions, yielding conflicting results. It must be emphasized that a relationship between fibrinogen or other hemostatic factors and H. pylori infection has been demonstrated only in cross-sectional studies, many of which included ischemic heart disease patients. The present evidence supporting the association between H. pylori infection and ischemic heart disease is based on cross-sectional surveys, in which it is difficult to separate cause and effect. The high prevalence in the population of both H. pylori and ischemic heart disease makes it very difficult to establish a causal associati...Continue Reading

References

Mar 25, 1989·BMJ : British Medical Journal·K J MattilaM J Jokinen
Sep 4, 1987·JAMA : the Journal of the American Medical Association·W B KannelR B D'Agostino
Aug 23, 1984·The New England Journal of Medicine·L WilhelmsenG Tibblin
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May 1, 1994·British Heart Journal·M A MendallT C Northfield
May 3, 1997·BMJ : British Medical Journal·F ParenteG Bianchi Porro

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Citations

Aug 30, 2003·American Heart Journal·Raffaele De CaterinaMaria Teresa La Rovere
Mar 2, 2002·Fertility and Sterility·Emre SeliAydin Arici
Aug 18, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G R de Freitas, J Bogousslavsky
Oct 13, 2006·Current Opinion in Gastroenterology·Najeeb Zoubi, Chris J Dickinson

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