The Association Between hMLH1 and hMSH2 Polymorphisms and Renal Tumors in Northeastern China

Genetic Testing and Molecular Biomarkers
Zhaohui XingRuihua An

Abstract

Aim: Although hMLH1 and hMSH2 are closely associated with the development and drug resistance of multiple types of tumors, their role in renal tumors remains unclear. This study was designed to examine the relationship between renal tumor development and polymorphisms in the hMLH1 and hMSH2 genes. Methods: The study included 180 patients with renal tumors that were confirmed by pathological examination and 199 healthy controls. The clinical and pathological stages of the tumor samples were determined, and DNA was extracted from the peripheral blood of the subjects. Polymorphisms in the hMLH1 and hMSH2 loci were identified using the 1000 genomes database and the multiplex ligase detection method. Correlation analyses was performed using single nucleotide polymorphism tests. Results: 88.9% (160/180) of the tumor specimens were identified as clear cell renal cell carcinoma (CCRC) and 89.4% (161/180) were stage I carcinomas. Three hMLH1 and nine hMSH2 polymorphic sites were identified, and the frequency of the AA genotype of the hMSH2 rs2303424 variant was found to be significantly higher in the renal tumor group (odds ratio [OR] = 1.37, 95% confidence interval [CI]: 1.02-1.86) in the additive model (p = 0.029), the recessive ...Continue Reading

References

Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Mar 27, 2003·Gene·Michitsune AritaHiroyuki Shimatake
May 29, 2003·The Journal of Urology·Masao DeguchiRajvir Dahiya
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Sun Ha ParkJae Yong Park
Dec 13, 2005·The New England Journal of Medicine·Herbert T Cohen, Francis J McGovern
Feb 3, 2006·International Journal of Cancer. Journal International Du Cancer·Eri AraiSetsuo Hirohashi
Dec 25, 2007·Cell Research·Guo-Min Li
Dec 28, 2007·European Urology·Monish AronInderbir S Gill
Mar 8, 2008·BJU International·Antonio Rubio-Del-CampoJulio Escribano
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jun 3, 2010·Nature Reviews. Genetics·Jonathan Marchini, Bryan Howie
Sep 3, 2010·Oncology Reports·Giuseppe AltavillaLuciano Giacomelli
Jul 16, 2013·International Journal of Cancer. Journal International Du Cancer·Lauren E McCulloughMarilie D Gammon
May 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Laleh Ehsani, Adeboye O Osunkoya
Nov 14, 2015·Handbook of Clinical Neurology·Prashant Chittiboina, Russell R Lonser
Mar 16, 2016·Annals of Surgical Oncology·Yi-Chen HsiehHung-Yi Chiou
Aug 17, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Katarzyna Karpińska-KaczmarczykElżbieta Urasińska
Nov 12, 2016·Oncotarget·Cheng ZhangKaifeng Wang
Jul 12, 2017·Current Protocols in Human Genetics·Babi Ramesh Reddy Nallamilli, Madhuri Hegde
Jan 25, 2018·Journal of Cancer Research and Clinical Oncology·Francesca SanguedolceLuigi Cormio
Jun 9, 2018·Journal of Translational Medicine·Yosr HamdiUNKNOWN PEC Consortium

❮ Previous
Next ❯

Methods Mentioned

BETA
blood
PCR
genotyping

Software Mentioned

Haploview

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.