The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis

OncoTargets and Therapy
Ling MinXia Zhao

Abstract

This work aims to explore whether HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. A comprehensive search was conducted for literature published from January 2007 to July 2017. The pooled odds ratios (ORs) and the corresponding 95% CIs were calculated using the Revman 5.2 software. Eighteen articles of 36 case-control studies were enrolled including six HOTAIR polymorphisms and 10 cancer types. The results showed that cancer risk was elevated in recessive mutation of rs12826786 (TT vs CC+CT: OR =1.55, 95% CI =1.19, 2.03; TT+CT vs CC: OR =1.23, 95% CI =1.04, 1.46; TT vs CC: OR =1.67, 95% CI =1.24, 2.24; T vs C: OR =1.24, 95% CI =1.09, 1.40) and rs920778 (TT vs CC+CT: OR =1.73, 95% CI =1.30, 2.30; TT+CT vs CC: OR =1.40, 95% CI =1.16, 1.70; TT vs CC: OR =1.83, 95% CI =1.25, 2.68; T vs C: OR =1.37, 95% CI =1.18, 1.59), while the results for polymorphisms of rs7958904, rs4759314, rs874945, and rs1899663 were insignificant. The stratified results for Chinese population were consistent with the overall group analysis. Our meta-analysis showed that HOTAIR polymorphisms of rs12826786 and rs920778 were correlated with increased cancer risk, while rs7958904, rs4759314, rs874945, and...Continue Reading

Citations

May 3, 2019·Cancer Biomarkers : Section a of Disease Markers·Dimitra-Ioanna LampropoulouMaria Gazouli
Feb 25, 2020·International Journal of Immunogenetics·Azadeh RakhshanMohammad Taheri
Dec 3, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Sahra EsmkhaniReza Mirfakhraie
Jan 7, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Taruna RajagopalNageswara Rao Dunna
Mar 23, 2021·World Journal of Clinical Cases·Dimitra Ioanna LampropoulouDimitrios Filippou

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Methods Mentioned

BETA
genotyping

Software Mentioned

STATA
Revman

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