PMID: 9166297May 1, 1997Paper

The association between hypertensive disorders of pregnancy and abnormal second-trimester maternal serum levels of hCG and alpha-fetoprotein

Obstetrics and Gynecology
L P MorssinkA Mantingh

Abstract

To examine the association between hypertensive disorders of pregnancy and second-trimester maternal serum alpha-fetoprotein (MSAFP) and hCG levels. The proportions of abnormal second-trimester MSAFP and hCG levels in the serum samples from 65 women with true pregnancy-induced hypertension or preeclampsia (cases) were compared to the proportions of abnormal levels in all 1943 women without this disorder in the same cohort in a hospital setting. Maternal serum alpha-fetoprotein and hCG levels of the 65 cases also were compared to those of 325 completely uncomplicated matched control pregnancies, selected from the same cohort. Fisher exact test and Student t test were used for statistical analysis and P < .05 was considered statistically significant. An MSAFP level at least 2.5 multiples of the median (MoM) was found in two of 65 cases (3.1%) and in 27 of 1943 women (1.4%) in the rest of the cohort, a nonsignificant difference (relative risk [RR] = 2.2; P = .24). The statistical power to identify a significant difference for this RR was .27. An hCG level of at least 2.5 MoM was found in six cases (9.2%) and in 89 (4.6%) of women in the rest of the cohort, also a nonsignificant difference (RR = 2.0; P = .12). The statistical power...Continue Reading

References

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Citations

Jun 27, 2014·Journal of Obstetrics and Gynaecology of India·Kiran YadavKamlesh Verma
Feb 16, 2000·Obstetrics and Gynecology·R HietalaT Laatikainen
Jul 10, 2003·Clinics in Laboratory Medicine·Deirdre J LyellLinda C Giudice
Jun 28, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A J AntsaklisS S Michalas
Feb 13, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Reli HershkovitzMoshe Mazor
Aug 25, 2001·Paediatric and Perinatal Epidemiology·C HolzmanUNKNOWN Prematurity Study Group
Dec 29, 1998·Current Opinion in Obstetrics & Gynecology·L Wilkins-Haug
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·T S Mikic, P Johnson
Jun 10, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·N J SebireK H Nicolaides
Nov 13, 2004·Fetal Diagnosis and Therapy·Bojana Brajenović-MilićMiljenko Kapović
May 20, 2014·Seminars in Perinatology·Zeynep Alpay SavasanRay O Bahado-Singh
Jul 21, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L P Morssink
Mar 30, 2000·American Journal of Obstetrics and Gynecology·B HaddadB M Sibai
Dec 31, 2014·Archives of Gynecology and Obstetrics·Pongsun PuntachaiTheera Tongsong
Oct 6, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reli HershkovitzMoshe Mazor
Dec 6, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Roiz-HernándezM Fernández-Mejía
Dec 2, 2004·Obstetrics and Gynecology·Agustin Conde-AgudeloMarshall Lindheimer
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia

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