The association between interleukin-18 and pulmonary sarcoidosis: a meta-analysis

Scandinavian Journal of Clinical and Laboratory Investigation
Ding-Hua LiuKe Chen

Abstract

To assess the association between interleukin-18 (IL-18) and pulmonary sarcoidosis. The Medline, Embase and Cochrane databases were searched to identify relevant studies. Studies were eligible for inclusion if they enrolled newly-diagnosed, untreated pulmonary sarcoidosis patients with IL-18 measurement in bronchoalveolar lavage fluid (BALF) or blood. A randomized effects model was used to pool six relevant studies. The IL-18 levels of BALF and blood in patients with pulmonary sarcoidosis were significantly higher than those in control subjects (p = 0.0001, p = 0.04, respectively). This meta-analysis has observed some evidence showing that the published results from these studies indicated the statistically significant association between IL-18 and pulmonary sarcoidosis.

References

May 1, 1977·Journal of Clinical Pathology·D N MitchellK F Hinson
Oct 8, 1998·The European Respiratory Journal·J Müller-Quernheim
Jan 20, 1999·The Journal of Allergy and Clinical Immunology·C A Dinarello
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M GreeneN G McElvaney
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·K ShigeharaN Sato
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K ShigeharaN Sato
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Shanthi Paramothayan, Paul W Jones
Jun 1, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Katerina M AntoniouNikolaos M Siafakas
Oct 4, 2006·Respiratory Medicine·Robert KieszkoJanusz Milanowski

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Citations

Jun 15, 2013·Paediatric Respiratory Reviews·Henry J Rozycki, Wei Zhao
Aug 13, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Ding-Hua LiuChun-Mei Huang

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