The association between ischemic and jeopardized myocardia and all-cause mortality in patients with peripheral artery disease

Vascular Medicine
Tarek A HammadMehdi H Shishehbor

Abstract

Peripheral artery disease (PAD) is associated with increased mortality and concomitant coronary artery disease (CAD). However, it is unclear whether uncovering the presence of functional coronary ischemia by single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) would further help stratifying that excess risk. From January 2000 to 2009, 4294 individuals underwent cardiac stress testing within 180 days of ankle-brachial index (ABI) measurements. Of these, 645 had PAD and SPECT MPI stress testing. Abnormal ABI was defined as ⩽ 0.9 or prior lower extremity arterial revascularization. Myocardial ischemic burden and total jeopardized myocardium were represented by the summed difference score (SDS) and summed stress score (SSS), respectively. Univariate and multivariable Cox proportional hazard analyses were used to study the impact of SDS and SSS on all-cause mortality. Additionally, using a hierarchical approach, we examined the step-wise addition of post-stress test coronary and lower extremity arterial revascularizations as time-varying covariates on outcomes. We found no significant difference in all-cause mortality between patients with ischemic myocardium (SDS > 0) and those without (SDS = 0) (ad...Continue Reading

References

Jan 13, 2006·JAMA : the Journal of the American Medical Association·Deepak L BhattUNKNOWN REACH Registry Investigators
Feb 16, 2006·JAMA : the Journal of the American Medical Association·Mehdi H ShishehborMichael S Lauer
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
May 2, 2009·The American Journal of Cardiology·Kenichi HiroseAkira Yamashina
Oct 16, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ryo NakazatoPiotr J Slomka
Nov 20, 2012·Circulation·Victor AboyansUNKNOWN Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia

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Methods Mentioned

BETA
coronary bypass
coronary artery bypass

Software Mentioned

SDS
SAS

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