The association between lead and cadmium co-exposure and renal dysfunction

Ecotoxicology and Environmental Safety
Xiao ChenTaiyi Jin

Abstract

Both cadmium (Cd) and lead (Pb) exposure can induce kidney damage. However, the effects of combined exposure to Cd and Pb on renal function at environmental levels have not been fully clarified. In this study we investigated the renal function in a Chinese population co-exposed to Cd and Pb. A total of 331 subjects (215 women and 116 men), living in either a control or a polluted area, were included in this study. Cd and Pb in blood and urine (BCd, BPb, UCd, and UPb), and kidney effect markers including urinary N-acetyl-β-D-glucosaminidase (UNAG) and estimated glomerular filtration rate (eGFR), were determined, and the association between exposure markers and renal effect biomarkers were analyzed. The exposure levels in the polluted area were significantly higher than in the control area (all p < 0.01). The eGFR of subjects in the polluted area was decreased compared with that in the control area (p < 0.01). The subjects with high BCd/BPb (BCd ≥ 2 μg/L, BPb ≥ 100 μg/L) or high UCd/UPb (UCd ≥ 3 μg/g creatinine, UPb ≥ 10 μg/g creatinine) showed higher UNAG and UALB levels compared with other subgroups (p < 0.01). The probability of having elevated UNAG in subjects with high BCd/BPb was greater than those with low BCd/BPb [odds ra...Continue Reading

Citations

Jun 14, 2019·Biological Trace Element Research·Tomoyuki Kawada
Nov 26, 2020·Biological Trace Element Research·Ying LiAnshan Shan
Oct 18, 2020·Toxics·Soisungwan SatarugKenneth R Phelps
Feb 1, 2021·Environmental Toxicology and Pharmacology·Ángeles C Ochoa-MartínezIván N Pérez-Maldonado
Nov 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jian-Ri LiChun-Jung Chen
Apr 12, 2021·Environmental Science and Pollution Research International·Zihan ChenXijin Xu
May 1, 2021·International Journal of Environmental Research and Public Health·Saruda Kuraeiad, Manas Kotepui
Aug 28, 2021·Children·Yuri Levin-SchwartzAlison P Sanders

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