The Association Between Macroscopic Arteriosclerosis of the Renal Artery, Microscopic Arteriosclerosis, Organ Discard, and Kidney Transplant Outcome.

Transplantation
Anke KeijbeckCyril Moers

Abstract

During organ retrieval, surgeons estimate the degree of arteriosclerosis and this plays an important role in decisions on organ acceptance. Our study aimed to elucidate the association between macroscopic renal artery arteriosclerosis, donor kidney discard, and transplant outcome. We selected all transplanted and discarded kidneys in the Netherlands between January 1, 2000, and December 31, 2015, from deceased donors aged 50 y and older, for which data on renal artery arteriosclerosis were available (n = 2610). The association between arteriosclerosis and kidney discard, the relation between arteriosclerosis and outcome, and the correlation between macroscopic and microscopic arteriosclerosis were explored. Macroscopic arteriosclerosis was independently associated with kidney discard (odds ratio [OR], 1.36; 95% confidence interval [CI], 1.02-1.80; P = 0.03). Arteriosclerosis (any degree) was not significantly associated with delayed graft function (OR, 1.16; 95% CI, 0.94-1.43; P = 0.16), estimated glomerular filtration rate 1-y posttransplant (B, 0.58; 95% CI, -2.07 to 3.22; P = 0.67), and long-term graft survival (hazard ratio, 1.07; 95% CI, 0.86-1.33; P = 0.55). There was a significant association between mild arteriosclerosi...Continue Reading

References

Jan 15, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F C FervenzaJ Petersen
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Jan 28, 2010·Histopathology·Maarten G J SnoeijsCarine J Peutz-Kootstra
Jul 17, 2012·American Journal of Nephrology·Tadashi SofueMasakazu Kohno
Apr 25, 2015·Advances in Chronic Kidney Disease·Soon Hyo Kwon, Lilach O Lerman
Dec 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Haas
Nov 23, 2016·Advances in Experimental Medicine and Biology·Robert SchoepeGeoffrey Teehan
Apr 11, 2018·Current Hypertension Reports·Peter W de LeeuwAbraham A Kroon
Nov 14, 2018·Journal of Computer Assisted Tomography·Nagina MalguriaElliot K Fishman

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Methods Mentioned

BETA
biopsy
light microscopy
biopsies
intragraft

Software Mentioned

Eurotransplant

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