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The association between mannose-binding lectin gene polymorphism and rheumatic heart disease

Human Immunology

Dec 19, 2006

Iara Jose Messias ReasonR Steffensen

Abstract

Mannan-binding lectin (MBL) is an innate pattern recognition molecule known to play a key role in pathogen clearance. As MBL2 gene polymorphism is associated to an increased susceptibility to infection, we aimed to determine genetic variations in the MBL2 gene in rheumatic heart disease...read more

Mentioned in this Paper

Gene Polymorphism
Real-Time Polymerase Chain Reaction
Systemic Inflammatory Response Syndrome
Mannose Binding Lectin
Exons
PRPF40A gene
Pathogenic Organism
Promoter
MBL2 protein, human
Autoimmune Diseases
Paper Details
References
  • References32
  • Citations30
1234
  • References32
  • Citations30
123

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Rheumatic heart disease, the sequel of acute rheumatic fever, continues to be a common health problem in the developing world, causing morbidity and mortality among both children and adults. Discover the latest research on rheumatic heart disease here.

Complement Pathway: Mannose-Binding Lectin

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The association between mannose-binding lectin gene polymorphism and rheumatic heart disease

Human Immunology

Dec 19, 2006

Iara Jose Messias ReasonR Steffensen

PMID: 17174748

DOI: 10.1016/j.humimm.2006.08.296

Abstract

Mannan-binding lectin (MBL) is an innate pattern recognition molecule known to play a key role in pathogen clearance. As MBL2 gene polymorphism is associated to an increased susceptibility to infection, we aimed to determine genetic variations in the MBL2 gene in rheumatic heart disease...read more

Mentioned in this Paper

Gene Polymorphism
Real-Time Polymerase Chain Reaction
Systemic Inflammatory Response Syndrome
Mannose Binding Lectin
Exons
PRPF40A gene
Pathogenic Organism
Promoter
MBL2 protein, human
Autoimmune Diseases

Similar Papers Found In These Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Rheumatic Heart Disease

Rheumatic heart disease, the sequel of acute rheumatic fever, continues to be a common health problem in the developing world, causing morbidity and mortality among both children and adults. Discover the latest research on rheumatic heart disease here.

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The Journal of Infectious Diseases

The association between mannan-binding lectin gene polymorphism and clinical leprosy: new insight into an old paradigm

The Journal of Infectious DiseasesOctober 9, 2007
I J T De Messias-ReasonJ F J Kun
Paper Details
References
  • References32
  • Citations30
1234
  • References32
  • Citations30
123
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