Abstract
Macrovascular disease (MVD), especially coronary heart disease, is the most common cause of mortality in Type 2 diabetes. We assessed the association between demographic and clinical variables (particularly HbA1c) and prevalent MVD at time of enrollment into the VA Diabetes Trial (VADT), a 7-year randomized trial to determine whether intensive glycemic control will reduce risk of MVD events in older participants with established Type 2 diabetes. We compared the demographic, treatment, and clinical characteristics of participants with and without known MVD, then assessed the interaction of multiple variables with HbA1c. Logistic regression models evaluated the association between HbA1c quartiles and prevalence of MVD, adjusting for potentially confounding variables. Several variables were associated with prevalent MVD (age, duration of diabetes, insulin use but not daily dosage, smoking history, hypertension, BMI, Caucasian race, non-Hispanic ethnicity, lower HDL cholesterol, higher triglycerides, lower LDL cholesterol, and statin use). In univariate analysis, there was no association of HbA1c with MVD (mean: 9.4+/-1.46% in those with MVD, 9.5+/-1.58% in those without). Multivariate analyses found little confounding of the lack ...Continue Reading
References
May 11, 1979·JAMA : the Journal of the American Medical Association·W B Kannel, D L McGee
Dec 1, 1986·Diabetes·M W KnuimanI J Constable
May 1, 1995·Diabetes Research and Clinical Practice·Y OhkuboM Shichiri
May 11, 1995·The New England Journal of Medicine·A S KrolewskiJ H Warram
Feb 1, 1995·Diabetes Care·R Klein
Aug 1, 1994·Diabetes·J KuusistoM Laakso
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 12, 1998·Annals of Internal Medicine·S VijanR A Hayward
Jul 23, 1998·The New England Journal of Medicine·S M HaffnerM Laakso
Sep 11, 1998·BMJ : British Medical Journal
Aug 11, 2000·BMJ : British Medical Journal·I M StrattonR R Holman
Oct 7, 2000·Diabetes Care·S R LevinC K Silbert
Jan 5, 2002·The American Journal of Medicine·E S HuangD E Singer
Oct 30, 2003·Journal of Diabetes and Its Complications·Carlos AbrairaUNKNOWN VA Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2
Apr 29, 2004·Diabetes Care·Nicholas L SmithStephan D Fihn
Sep 24, 2004·Annals of Internal Medicine·Kay-Tee KhawNicholas Day
Sep 24, 2004·Annals of Internal Medicine·Elizabeth SelvinSherita Hill Golden
Citations
Mar 6, 2010·Diabetologia·G O'MalleyS Caprio
Dec 19, 2008·The New England Journal of Medicine·William DuckworthUNKNOWN VADT Investigators
Aug 2, 2008·Diabetes, Obesity & Metabolism·C AbrairaUNKNOWN VADT Group
Dec 14, 2011·Diabetes, Obesity & Metabolism·P Hamet
Sep 4, 2008·Acta Diabetologica·Mike A Baxter
Jan 25, 2016·Reviews in Endocrine & Metabolic Disorders·L MonnierD R Owens
Nov 8, 2011·Journal of Diabetes and Its Complications·William C DuckworthUNKNOWN Investigators of the VADT
Apr 28, 2009·European Journal of Internal Medicine·I M Jazet, A E Meinders
Aug 8, 2008·Primary Care Diabetes·Rien ten BrinkeDavid Ikkersheim
Aug 19, 2007·Clinical Therapeutics·Anthony Barnett
Oct 6, 2007·Molecular Nutrition & Food Research·Cheng-Tzu LiuChong-Kuei Lii
Jan 29, 2013·Journal of Diabetes Investigation·Takuo NambuShogo Oki
Jun 5, 2012·International Journal of Cardiology·Norihiro FurusyoJun Hayashi
Jun 4, 2015·The New England Journal of Medicine·Rodney A HaywardUNKNOWN VADT Investigators
May 16, 2013·Biochimica Et Biophysica Acta·Norihiro Furusyo, Jun Hayashi
Nov 25, 2016·Postgraduate Medicine·A Enrique Caballero
Sep 18, 2008·Angiology·Ahmet SoyluMehmet Tokac
Aug 10, 2017·Nutrients·Hana KahleovaNeal Barnard
Jun 9, 2017·The Cochrane Database of Systematic Reviews·Marinella RuospoGiovanni Fm Strippoli
Jun 6, 2019·The New England Journal of Medicine·Peter D ReavenUNKNOWN VADT Investigators
Aug 20, 2018·Endocrine·Bao SunWei Zhang
Mar 15, 2019·Endocrine·Bao SunWei Zhang
Aug 30, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Faramarz Ismail-Beigi, Etie S Moghissi
Nov 30, 2018·Cardiovascular Diabetology·Mikhail KosiborodUNKNOWN DISCOVER investigators
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity