The association between missing teeth and non-alcoholic fatty liver disease in adults

Journal of Clinical Periodontology
Feng QiaoKaijun Niu

Abstract

Long-term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non-alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD. This study evaluated the association between missing teeth and presence of NAFLD in a general population. A cross-sectional study of 24,470 adults was carried out from the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. The self-reported number of missing teeth (excluding third molars) was recorded and classified into four categories: 0, 1-2, 3-5, and ≥6. The NAFLD was diagnosed by the liver ultrasonography. Associations were analysed by adjusted multivariable logistic regression. The multivariable-adjusted odds ratios (95% confidence interval) of NAFLD across the categories of missing teeth were as follows: in males, 1.00 (reference), 1.04 (0.93-1.16), 1.06 (0.90-1.24), and 1.40 (1.09-1.81) (p for trend = 0.04); in females, 1.00 (reference), 0.98 (0.83-1.15), 1.11 (0.90-1.37), and 1.07 (0.77-1.48) (p for trend = 0.45). The number of missing teeth was associated with a higher presence of NAFLD in males bu...Continue Reading

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Citations

Oct 26, 2018·Clinical Oral Investigations·Mohammad Sultan AlakhaliEsam Halboub
Aug 2, 2019·Journal of Dental Research·J A WeintraubB A Dye
Jul 6, 2020·Journal of Clinical Periodontology·You ChenXi Zhang
May 1, 2021·International Journal of Molecular Sciences·Masahiro HatasaSayaka Katagiri

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