The association between mood and anxiety disorders, and coronary heart disease in Brazil: a cross-sectional analysis on the Brazilian longitudinal study of adult health (ELSA-Brasil)

Frontiers in Psychology
Andrew H KempPaulo A Lotufo

Abstract

Associations between major depressive disorder (MDD) and coronary heart disease (CHD) have been established, and these associations increase risk of future morbidity and mortality. Prior research has been carried out in high-income countries. Here we examine associations between the mood and anxiety disorders, and CHD in a large cohort at baseline from Brazil, a country facing a variety of challenges that may affect these associations. Participants included 15,105 civil servants aged 35 to 74 at baseline (2008-2010) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). CHD (N = 721) included self-reported angina pectoris (n = 305), myocardial infarction (n = 259) and coronary revascularization (n = 239). Hierarchical logistic regression analyses were conducted to estimate odds ratios and confidence intervals. Major findings indicate that comorbid MDD and anxiety disorders (n = 434) are associated with a threefold increase in CHD, MDD alone (n = 170) with a twofold increase in CHD, while generalized anxiety disorder alone (n = 1,394) and mixed anxiety and depression disorder (n = 1,844) - symptoms present, but diagnostic threshold not reached - are associated with a 1.5-fold increase in CHD, after full adjustment ...Continue Reading

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Citations

Oct 11, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrew H Kemp
May 30, 2016·The American Journal of Cardiology·Itamar S SantosIsabela M Bensenor
Aug 17, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Paulo Andrade Lotufo
Sep 16, 2017·Terapevticheskiĭ arkhiv·F I Belialov
Feb 2, 2019·Frontiers in Psychiatry·Ralf HartmannUlrich Hegerl

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