The association between nonalcoholic fatty liver disease and risk of colorectal adenoma and cancer incident and recurrence: a meta-analysis of observational studies

Expert Review of Gastroenterology & Hepatology
Jin ChenJunping Shi

Abstract

Lifestyle modification plays a key role in nonalcoholic fatty liver disease (NAFLD) and colorectal adenoma and/or cancer (CRA/CRC) development. However, the association between NAFLD and the risk of CRA/CRC has not been carefully evaluated. In this meta-analysis, we assessed 21 eligible studies including 124,206 participants to determine the association between NAFLD and the risk of incident and recurrent CRA/CRC. NAFLD presence was associated with an increased risk of any incident CRA (aOR: 1.30, 95% CI: 1.19-1.43) and advanced incident CRA/CRC (aOR: 1.57, 95% CI: 1.21-2.04). The severity of NAFLD affected this correlation: compared to mild and/or moderate NAFLD, severe NAFLD was associated with an increased risk of incident CRA/CRC (aOR: 2.19, 95% CI: 1.33-3.60). Although pooled cOR revealed that NAFLD was associated with an increased risk of recurrent CRA/CRC (cOR = 1.73; 95% CI: 1.12-2.68), after adjustment for confounding factors, NAFLD had less correlation with the risk of recurrent CRA/CRC (aOR: 1.81, 95% CI: 0.70-4.65). The presence and severity of NAFLD are associated with an increased risk of incident CRA/CRC. However, there is insufficient evidence to indicate that NAFLD is associated with an increased risk of recurr...Continue Reading

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Citations

Nov 28, 2019·Expert Review of Gastroenterology & Hepatology·Yan LvHai-Jun Zhang
Jun 25, 2020·Journal of Gastroenterology and Hepatology·Wenxia ChenXianbin Cai
Apr 8, 2020·BioMed Research International·Gitana Maria AcetoMaria Cristina Curia
Jan 20, 2021·Diabetes, Obesity & Metabolism·Bertrand CariouArun J Sanyal
May 1, 2021·International Journal of Molecular Sciences·Maria NotarnicolaCaterina Messa

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