The Association Between Parkinson's Disease Motor Impairments and Pain

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Natalie E AllenNiamh Moloney

Abstract

This study aimed to: 1) examine the severity and frequency of pain and the extent to which pain interferes with work and 2) explore the contributions of motor impairments to pain in people with Parkinson's disease (PD). Pain severity, frequency and the impact of pain on work were determined using subscores from the SF-36(TM), Parkinson's Disease Questionnaire and SF-12v2(TM), respectively, in 231 people with Parkinson's disease. Motor impairments were measured using the Unified Parkinson's Disease Rating Scale. Freezing of gait was determined as its presence or absence in the last month. Associations between impairments and pain were examined using logistic regression. Pain was reported by 187 (81%) participants, with 91 (39%) reporting pain of moderate severity or worse. Pain interfered with work to some extent in 158 (68%) participants. After adjusting for age and gender, increased rigidity was associated with higher pain frequency and more pain that interfered with work (for both models, Odds Ratio = 1.14, 95% confidence interval 1.0-1.3). Tremor was not associated with any measures of pain and motor impairments were not associated with pain severity. Most people with PD experience pain at least monthly and pain interferes w...Continue Reading

References

May 1, 1976·Neurology·S R SniderL J Cote
Jan 1, 1986·Movement Disorders : Official Journal of the Movement Disorder Society·C G GoetzD C Garron
Jun 1, 1995·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·V PetoR Greenhall
Mar 22, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·M TinazziG Defazio
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
Nov 7, 2006·Journal of Pain and Symptom Management·Mark A LeeWendy M Prentice
May 27, 2008·Experimental Neurology·Heiko Braak, Kelly Del Tredici
Jun 12, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Laurence Nègre-PagèsUNKNOWN DoPaMiP Study Group
Dec 23, 2008·Pain·A G BeiskeE Svensson
Mar 27, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Uwe EhrtDag Aarsland
Jun 16, 2009·Lancet·Andrew J LeesTamas Revesz
Feb 27, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Blair Ford
Aug 31, 2010·Clinical Neurology and Neurosurgery·Hasmet A HanagasiMurat Emre
May 27, 2011·Journal of Neurology·Marlies van NimwegenMarten Munneke
Sep 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Ainhi D Ha, Joseph Jankovic
Apr 18, 2012·Nature Reviews. Neurology·Gunnar Wasner, Günther Deuschl
Aug 7, 2013·Parkinsonism & Related Disorders·Bernd MüllerOle-Bjørn Tysnes
Sep 17, 2013·Annals of Neurology·C Warren Olanow, Anthony H V Schapira
Oct 1, 2013·Clinical Neurology and Neurosurgery·Abdul Qayyum RanaSumaiya Khondker
Nov 13, 2013·Nature Reviews. Neurology·Antonella ConteAlfredo Berardelli
Feb 12, 2014·JAMA Neurology·Mary Ann Thenganatt, Joseph Jankovic
Jan 2, 2015·Neurology·Colleen G CanningVictor S C Fung
Feb 5, 2015·Journal of Parkinson's Disease·Natalie E AllenColleen G Canning

❮ Previous
Next ❯

Citations

Nov 2, 2016·Parkinson's Disease·Marcelo Rezende Young BloodCarlos Henrique Ferreira Camargo
May 29, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Martinez-MartinUNKNOWN EUROPAR and MDS Non-motor PD Study Group
Jun 30, 2019·Disease Models & Mechanisms·Lucie ValekIrmgard Tegeder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Madaline B HarrisonG Frederick Wooten
Movement Disorders : Official Journal of the Movement Disorder Society
Elan D LouisDevangere P Devanand
© 2021 Meta ULC. All rights reserved