The association between partner bereavement and melanoma: cohort studies in the U.K. and Denmark

The British Journal of Dermatology
A Y S WongS M Langan

Abstract

Psychological stress is commonly cited as a risk factor for melanoma, but clinical evidence is limited. This study aimed to evaluate the association between partner bereavement and (i) first-time melanoma diagnosis and (ii) mortality in patients with melanoma. We conducted two cohort studies using data from the U.K. Clinical Practice Research Datalink (1997-2017) and Danish nationwide registries (1997-2016). In study 1, we compared the risk of first melanoma diagnosis in bereaved vs. matched nonbereaved people using stratified Cox regression. In study 2 we estimated hazard ratios (HRs) for death from melanoma in bereaved compared with nonbereaved individuals with melanoma using Cox regression. We estimated HRs separately for the U.K. and for Denmark, and then pooled the data to perform a random-effects meta-analysis. In study 1, the pooled adjusted HR for the association between partner bereavement and melanoma diagnosis was 0·88 [95% confidence interval (CI) 0·84-0·92] across the entire follow-up period. In study 2, we observed increased melanoma-specific mortality in people experiencing partner bereavement across the entire follow-up period (HR 1·17, 95% CI 1·06-1·30), with the peak occurring during the first year of follow-u...Continue Reading

References

Nov 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B R CassilethE J Lusk
Jun 13, 1985·The New England Journal of Medicine·B R CassilethC Miller
Jan 1, 1970·American Journal of Epidemiology·J A Lee, G B Hill
Aug 1, 1967·Journal of Psychosomatic Research·T H Holmes, R H Rahe
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Sep 26, 1997·Journal of Psychosomatic Research·M A Miller, R H Rahe
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P N ButowS M Dunn
Mar 5, 2003·Brain, Behavior, and Immunity·Eric V Yang, Ronald Glaser
Oct 22, 2003·The Journal of Ambulatory Care Management·Azeem Majeed
Jul 28, 2004·Archives of Dermatological Research·Ana Cristina ScarparoAna Maria de Lauro Castrucci
Aug 30, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Dec 6, 2005·Archives of Disease in Childhood·S A OliveriaC Jorgensen
Jan 31, 2006·Cell Biochemistry and Function·Ana Cristina ScarparoAna Maria de Lauro Castrucci
Feb 25, 2006·Nature Reviews. Cancer·Michael H AntoniAnil K Sood
Aug 19, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Carlos A Reyes OrtizJames S Goodwin
May 22, 2008·Nature Clinical Practice. Oncology·Yoichi ChidaAndrew Steptoe
Jun 30, 2010·Dermatology Research and Practice·M SanzoS Moretti
Jul 8, 2010·International Journal of Cancer. Journal International Du Cancer·Philippa H YoulJoanne F Aitken
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Aug 4, 2011·Scandinavian Journal of Public Health·Karin Helweg-Larsen
Aug 4, 2011·Scandinavian Journal of Public Health·Marianne Lundkjær Gjerstorff
Aug 4, 2011·Scandinavian Journal of Public Health·Vibeke M Jensen, Astrid W Rasmussen
Dec 21, 2011·Archives of Dermatology·Geoffrey B YangJeremy S Bordeaux
Mar 22, 2012·Psychotherapy and Psychosomatics·Ulla-Sisko LehtoPirkko Kellokumpu-Lehtinen
Oct 12, 2012·The British Journal of Dermatology·E de VriesUNKNOWN EPIDERM Group
Dec 15, 2012·Pharmacoepidemiology and Drug Safety·Rachael BoggonMike A Richards
Dec 19, 2012·Clinics in Dermatology·Nadine Angele Kasparian
Apr 20, 2013·American Journal of Public Health·Sunil M ShahDerek G Cook
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
May 10, 2015·European Journal of Epidemiology·Jaimie L GradusHenrik Toft Sørensen
Jun 8, 2015·International Journal of Epidemiology·Emily HerrettLiam Smeeth
Sep 8, 2015·Contemporary Clinical Trials·Rebecca DerSimonian, Nan Laird
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Nov 15, 2016·Spatial and Spatio-temporal Epidemiology·Ulf StrömbergStefan Peterson
Feb 9, 2017·International Journal of Epidemiology·Thierry Boudemaghe, Ihssen Belhadj
Aug 5, 2017·Journal of Cancer Survivorship : Research and Practice·Ray M Merrill, Erin Johnson
Aug 10, 2017·Journal of Epidemiology and Community Health·Beatrice KennedyKatja Fall
Apr 25, 2018·Acta Oncologica·Thomas P AhernJaimie L Gradus
May 2, 2018·JAMA Dermatology·Cimarron E SharonGiorgos C Karakousis

❮ Previous
Next ❯

Citations

May 12, 2020·The British Journal of Dermatology·J A TalaganisA J Stratigos

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SAS
Stata
MP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.